Compile Data Set for Download or QSAR
maximum 50k data
Found 230 Enz. Inhib. hit(s) with all data for entry = 10388
TargetCoagulation factor V(Homo sapiens (Human))
Maastricht University

Curated by ChEMBL
LigandPNGBDBM50376417(CHEMBL261865)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329000(CHEMBL1270373 | potassium 5-(biphenyl-4-ylmethyl)-...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329001(CHEMBL1270466 | potassium 4-(biphenyl-2-ylmethyl)-...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402653(CHEMBL2206734)
Affinity DataIC50:  2.34E+4nMAssay Description:Inhibition of PTP1B using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402647(CHEMBL2206732)
Affinity DataIC50:  2.42E+4nMAssay Description:Inhibition of PTP1B using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444601(CHEMBL3099881)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402649(CHEMBL2206736)
Affinity DataIC50:  2.69E+4nMAssay Description:Inhibition of PTP1B using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328990(CHEMBL1269961 | potassium 4-(biphenyl-3-ylmethyl)-...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402659(CHEMBL2206751)
Affinity DataIC50:  2.84E+4nMAssay Description:Inhibition of PTP1B using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329003(CHEMBL1270566 | potassium 4-(3-(1H-imidazol-1-yl)p...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of ADAMTS-4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328995(CHEMBL1270176 | potassium 4-(3-(1H-imidazol-1-yl)p...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of ADAMTS-4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM33453((3-Amino-[1,2,4]triazol-4-yl)-(4-methoxy-phenyl)-m...)
Affinity DataIC50: >3.00E+4nMpH: 8.0Assay Description:Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM33437((5-amino-3-phenyl-1,2,4-triazol-1-yl)-(3,4-dimetho...)
Affinity DataIC50: >3.00E+4nMpH: 8.0Assay Description:Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM33882((5-amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-chl...)
Affinity DataIC50: >3.00E+4nMpH: 8.0Assay Description:Inhibition of human matriptase measured after 15 mins at pH 8 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM33437((5-amino-3-phenyl-1,2,4-triazol-1-yl)-(3,4-dimetho...)
Affinity DataIC50: >3.00E+4nMpH: 8.0Assay Description:Inhibition of human kallikrein 14 measured after 15 mins at pH 8 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM33882((5-amino-3-pyridin-3-yl-1,2,4-triazol-1-yl)-(4-chl...)
Affinity DataIC50: >3.00E+4nMpH: 8.0Assay Description:Inhibition of human kallikrein 14 measured after 15 mins at pH 8 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5 [D153N](Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50438170(CHEMBL2407437)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human kallikrein 5 measured after 15 mins at pH 8 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402648(CHEMBL2206754)
Affinity DataIC50:  3.06E+4nMAssay Description:Inhibition of PTP1B using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor V(Homo sapiens (Human))
Maastricht University

Curated by ChEMBL
LigandPNGBDBM50423622(CHEMBL1614804)
Affinity DataIC50:  3.24E+4nMAssay Description:Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402650(CHEMBL2206756)
Affinity DataIC50:  3.31E+4nMAssay Description:Inhibition of VHR using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328998(CHEMBL1270274 | potassium 5-((3-phenyl-1,2,4-oxadi...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor V(Homo sapiens (Human))
Maastricht University

Curated by ChEMBL
LigandPNGBDBM50376417(CHEMBL261865)
Affinity DataIC50:  3.81E+4nMAssay Description:Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402670(CHEMBL2206729)
Affinity DataIC50:  4.01E+4nMAssay Description:Inhibition of MBP-fused recombinant wild type CDC25B3 using fluorescein 3,6 diphosphate as substrate measured for 30 mins in presence of 1 mM dithiot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor V(Homo sapiens (Human))
Maastricht University

Curated by ChEMBL
LigandPNGBDBM50376420(CHEMBL1162110)
Affinity DataIC50:  4.06E+4nMAssay Description:Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402652(CHEMBL2206735)
Affinity DataIC50:  4.13E+4nMAssay Description:Inhibition of PTP1B using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402654(CHEMBL2207337)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of PTP1B using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328999(CHEMBL1270372 | potassium 4-(3-phenylpropyl)-5-((3...)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402671(CHEMBL2206728)
Affinity DataIC50:  4.84E+4nMAssay Description:Inhibition of MBP-fused recombinant wild type CDC25B3 using fluorescein 3,6 diphosphate as substrate measured for 30 mins in presence of 1 mM dithiot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402662(CHEMBL2206743)
Affinity DataIC50:  5.73E+4nMAssay Description:Inhibition of MBP-fused recombinant wild type CDC25B3 using fluorescein 3,6 diphosphate as substrate measured for 30 mins in presence of 1 mM dithiot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50441584(CHEMBL2437179)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of human recombinant ADAMTS-5 using ARGSVILTV-KPIFEVSPSPL(biotinyl)K as substrate incubated 10 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor V(Homo sapiens (Human))
Maastricht University

Curated by ChEMBL
LigandPNGBDBM50376423(CHEMBL410427)
Affinity DataIC50:  6.29E+4nMAssay Description:Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444600(CHEMBL1462676)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444599(CHEMBL3099875)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50402651(CHEMBL2206752)
Affinity DataIC50:  7.58E+4nMAssay Description:Inhibition of VHR using fluorescein 3,6 diphosphate as substrate measured for 1 hr in presence of 1 mM dithiothreitolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444598(CHEMBL3099878)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444599(CHEMBL3099875)
Affinity DataIC50:  8.70E+4nMAssay Description:Inhibition of human kallikrein14 using Boc-Val-Pro-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444602(CHEMBL3099874)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444603(CHEMBL3099871)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibition of human kallikrein7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444600(CHEMBL1462676)
Affinity DataIC50:  9.60E+4nMAssay Description:Inhibition of human kallikrein14 using Boc-Val-Pro-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444603(CHEMBL3099871)
Affinity DataIC50:  9.80E+4nMAssay Description:Inhibition of matriptase (unknown origin) using Boc-Gln-Ala-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50444602(CHEMBL3099874)
Affinity DataIC50:  9.90E+4nMAssay Description:Inhibition of human kallikrein14 using Boc-Val-Pro-Arg-AMC as substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329004(CHEMBL1270567 | potassium 4-(3-(1H-imidazol-1-yl)p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328997(CHEMBL1270273 | potassium 4-(biphenyl-4-ylmethyl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329002(CHEMBL1270467 | potassium 4-(biphenyl-2-ylmethyl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329007(4-(3-imidazol-1-yl-propyl)-5-(2-(5-methyl-[1,2,4]o...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328992(CHEMBL1270068 | potassium 4-benzyl-5-((4-chlorophe...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328996(CHEMBL1270177 | potassium 4-(biphenyl-4-ylmethyl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329006(5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-3-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50329005(5-(4-chlorobenzyloxymethyl)-4-(4-phenylbenzyl)-3-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Lille

Curated by ChEMBL
LigandPNGBDBM50328994(CHEMBL1270070 | potassium 5-((4-chlorophenoxy)meth...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ADAMTS-5 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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