Found 19 Enz. Inhib. hit(s) with all data for entry = 50015598 TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of cMET (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Binding affinity to human SMO (181 to 787 residues) expressed in human HEK293 cells assessed as radioactivity incubated for 2 hrs in presence of H3-l...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of endogenous human Smo overexpressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase activity b...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of endogenous mouse Smo overexpressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase activity b...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of Smo D473H mutant (unknown origin) expressed in mouse NIH3T3 cells cotransfected with Gli luciferase reporter gene assessed as Gli lucif...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD3 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Antagonist activity at resistant Smo D473H mutant (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed ...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of wild type Smo (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase acti...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Antagonist activity at resistant Smo D473H mutant (unknown origin) in presence of GDC0449More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of Smo D473H mutant (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase a...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human VEGFR2 (789 to 1356 residues) assessed as reduction in autophosphorylation at Y1175 residues using poly (Glu4Tyr1) peptide and AT...More data for this Ligand-Target Pair
Affinity DataKd: 1nMAssay Description:Binding affinity to CK1alpha (unknown origin) using casein as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
