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Found 6 Enz. Inhib. hit(s) with Target = 'DNA gyrase subunit A/B' and Ligand = 'BDBM50050549'
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50:  47nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50:  47nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase using positively supercoiled pBR322 DNA as substrate incubated for 25 mins by ethidium bromide stainin...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50:  60nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50:  170nMAssay Description:Inhibition of Staphylococcus aureus Gyrase supercoiling activity assessed as reduction in supercoiling pBR322 DNA by measuring relaxation by bromophe...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50:  244nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandPNGBDBM50050549(GSK2140944 | Gepotidacin)
Affinity DataIC50:  374nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30...More data for this Ligand-Target Pair