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Found 11 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM50518965'
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of human EGFR L858R/T790M mutant (696 to 1022 residues) expressed in insect sf9 cells in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of his-GST tagged human EGFR L858R/T790M double mutant expressed in insect cells incubated for 30 mins in presence of ATP by HTRF kinase a...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR L858R/T790M mutant expressed in human NCI-H1975 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  73nMAssay Description:Inhibition of human C-terminal His-tagged and N-terminal GST-tagged EGFR L858R/T790M/C797S triple mutant ( 668 to 1210 amino acids) expressed in bacu...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  100nMAssay Description:Inhibition of EGFR L858R/C797S mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells measured after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  428nMAssay Description:Inhibition of EGFR L858R mutant expressed in human NCI-H3255 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using Poly(Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  3.91E+3nMAssay Description:Inhibition of wild type EGFR expressed in human NCI-H2073 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50518965(CHEMBL4443062)
Affinity DataIC50:  4.21E+3nMAssay Description:Inhibition of wild type EGFR expressed in human A-431 cellsMore data for this Ligand-Target Pair