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Found 7 Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM349684'
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  90nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  1.80E+3nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  6.70nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in presence of BETP by BETP sensitized...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cells assessed as induction of beta-arrestin 2 recruitment incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  2.10E+3nMAssay Description:Agonist activity at GLP-1R (unknown origin) expressed in candidate selection CHO cells assessed as cAMP accumulation incubated for 30 mins by plate r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cell assessed as induction of beta-arrestin 2 recruitment incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM349684(2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in absence of BETP by plate reader met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed