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Found 4 Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50168703'
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168703(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-metho...)
Affinity DataKi:  18nMAssay Description:In vitro ability to inhibit des-Gly[125I-Tyr, DLeu, NMeLeu,Pro-NEt]-GnRH radioligand binding to the cloned human GnRH receptor stably expressed in HE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168703(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-metho...)
Affinity DataKi:  240nMAssay Description:Inhibition constant against monkey GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168703(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-metho...)
Affinity DataKi:  9.40E+3nMAssay Description:Inhibition constant against rat GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168703(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-metho...)
Affinity DataIC50:  480nMAssay Description:Inhibition of human GnRH receptor stimulated inositol phosphate accumulation in RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed