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Report error Found 4 Enz. Inhib. hit(s) with Target = 'Histamine H4 receptor' and Ligand = 'BDBM26390'
TargetHistamine H4 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26390(4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-ami...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.4 T: 25°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26390(4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-ami...)
Affinity DataKi:  6.31nMAssay Description:Displacement of [3H]histamine from human H4R receptor expressed in HEK293 cells at 10 uM after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26390(4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-ami...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]histamine displacement from human recombinant histamine H4 receptor expressed in SK-NM-C cells after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rat)
Abbott Laboratories

LigandPNGBDBM26390(4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-ami...)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/molepH: 7.4 T: 25°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed