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Found 5 Enz. Inhib. hit(s) with Target = 'Kappa-type opioid receptor' and Ligand = 'BDBM50266390'
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50266390((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50266390((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi:  38nMAssay Description:In vitro binding assay: The affinities of compounds for opioid receptors were determined by competitive inhibition of [3H]diprenorphine binding to ka...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50266390((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]diprenorphine from human KOPR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50266390((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataEC50:  101nMAssay Description:Agonist activity at human KOPR expressed in CHO cells assessed as enhancenment of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50266390((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataEC50:  1.63E+3nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as [35S]GTP-gamma-S binding after 3 hrs by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed