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Found 5 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM50437407'
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50437407(CHEMBL2408789 | US9023865, 6)
Affinity DataIC50:  0.152nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50437407(CHEMBL2408789 | US9023865, 6)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human ERK2 preincubated for 15 mins followed by addition of IMAP peptide substrate and ATP measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50437407(CHEMBL2408789 | US9023865, 6)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human ERK2 preincubated for 15 mins followed by addition of IMAP peptide substrate and ATP measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50437407(CHEMBL2408789 | US9023865, 6)
Affinity DataIC50:  0.204nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50437407(CHEMBL2408789 | US9023865, 6)
Affinity DataIC50:  0.205nMAssay Description:Inhibition of human ERK2 pre-incubation for 15 mins before substrate addition measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed