Report error Found 6 Enz. Inhib. hit(s) with Target = 'Phospholipase D2' and Ligand = 'BDBM87245'
Affinity DataIC50: 225nMT: 37°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:In vitro PLD activity is measured with an exogenous substrate assay as previously described (Brown, H. A. et al. (1993) Cell 75:1137-1144). Briefly, ...More data for this Ligand-Target Pair
Affinity DataIC50: 241nMAssay Description:Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of GFP-labelled human PLD2 HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:The ability of representative disclosed to block influenza infection was assessed in a cell-based assay using A549 human epithelial cells (ATCC CCL-1...More data for this Ligand-Target Pair
Affinity DataIC50: 384nMAssay Description:Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...More data for this Ligand-Target Pair
