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Found 5 Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP3 subtype' and Ligand = 'BDBM50414549'
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414549(CHEMBL563480)
Affinity DataKi:  1.26nMAssay Description:Antagonist activity at human EP3 receptor expressed in cells assessed as mobilization of intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414549(CHEMBL563480)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(RAT)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414549(CHEMBL563480)
Affinity DataKi:  6.31nMAssay Description:Inhibition of rat EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414549(CHEMBL563480)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414549(CHEMBL563480)
Affinity DataEC50: >2.51E+4nMAssay Description:Agonist activity at human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed