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Found 2 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase ROS [G2032R]' and Ligand = 'BDBM446757'
TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM446757((6R,15S)-9-fluoro-15-methyl- 2,11,16,20,21,24- hex...)
Affinity DataIC50:  14.3nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM446757((6R,15S)-9-fluoro-15-methyl- 2,11,16,20,21,24- hex...)
Affinity DataIC50:  157nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In DepthDetails US Patent