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Found 4 Enz. Inhib. hit(s) with Target = 'Purine nucleoside phosphorylase' and Ligand = 'BDBM50308521'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed