Found 23 Enz. Inhib. hit(s) with Target = 'Receptor tyrosine-protein kinase erbB-2' and Ligand = 'BDBM50161957'
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HER2 R896C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 1.96nMAssay Description:HER2: The compounds' inhibition of target modulation were determined as follows: BT474 cells were sorted in 96 well plates (20000 cells/well) wit...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HER2 V777L mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of wild type human GST-tagged HER2 (676 to end residues) expressed in baculovirus infected Sf9 cells incubated for 30 mins in presence of ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of HER2 D769H mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated fo...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 13.2nMAssay Description:Table B3: Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phospho...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 13.2nMAssay Description:Enzyme-linked immunosorbent assays (ELISA) were performed to measure phosphorylated ERBB2 levels. A capture antibody able to detect phosphorylated an...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of HER2 D769Y mutant (unknown origin) incubated for 120 mins in presence of 33P-ATP by P81 ion exchange cellulose chromatographyMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of HER2 phosphorylation (676 to 1255 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 15 mins i...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of human epidermal growth factor receptor-2 (HER-2) autophosphorylationMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Effective concentration against retinoic acid receptor alpha in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (4.6-8.9)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of human Her2More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant HER2 (676 to 1255 residues) (unknown origin) expressed in baculovirus infected sf9 cells autophosphorylation incubated for ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Irreversible inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of HER2 (unknown origin) in presence of substrate incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataEC50: 690nMAssay Description:Inhibition of human Her2 in SW620 cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataEC50: 2nMAssay Description:Inhibition of human Her2 in SKBR3 cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataEC50: 81nMAssay Description:Inhibition of human Her2 in A431 cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataKd: 6nMAssay Description:Binding constant for ERBB2 kinase domainMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataEC50: 2nMAssay Description:Inhibition of human Her2 in BT474 cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Shanghai Pharmaceuticals Holding
Curated by ChEMBL
Affinity DataEC50: 5nMAssay Description:Inhibition of HER2 phosphorylation in human BT-474 cells incubated for 3 hrs followed by replacement with fresh medium without compound measured afte...More data for this Ligand-Target Pair