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Found 5 Enz. Inhib. hit(s) with Target = 'Thymidylate synthase' and Ligand = 'BDBM18764'
TargetThymidylate synthase(Lactobacillus casei)
Unimore

LigandPNGBDBM18764(1,8-naphthalein derivative, 11 | 8-chloro-4,4-bis(...)
Affinity DataKi:  700nM ΔG°:  -34.5kJ/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM18764(1,8-naphthalein derivative, 11 | 8-chloro-4,4-bis(...)
Affinity DataKi:  730nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Cryptococcus neoformans)
Unimore

LigandPNGBDBM18764(1,8-naphthalein derivative, 11 | 8-chloro-4,4-bis(...)
Affinity DataKi:  9.60E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Università

Curated by ChEMBL
LigandPNGBDBM18764(1,8-naphthalein derivative, 11 | 8-chloro-4,4-bis(...)
Affinity DataKi:  1.30E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Unimore

LigandPNGBDBM18764(1,8-naphthalein derivative, 11 | 8-chloro-4,4-bis(...)
Affinity DataKi: >1.20E+5nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed