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Found 4 Enz. Inhib. hit(s) with Target = 'Thymidylate synthase' and Ligand = 'BDBM18768'
TargetThymidylate synthase(Lactobacillus casei)
Unimore

LigandPNGBDBM18768(1,8-naphthalein derivative, 15 | 4,4-bis(3,5-dibro...)
Affinity DataKi:  900nM ΔG°:  -33.9kJ/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Unimore

LigandPNGBDBM18768(1,8-naphthalein derivative, 15 | 4,4-bis(3,5-dibro...)
Affinity DataKi:  3.20E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Cryptococcus neoformans)
Unimore

LigandPNGBDBM18768(1,8-naphthalein derivative, 15 | 4,4-bis(3,5-dibro...)
Affinity DataKi:  4.00E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Unimore

LigandPNGBDBM18768(1,8-naphthalein derivative, 15 | 4,4-bis(3,5-dibro...)
Affinity DataKi: >1.10E+7nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed