Report error Found 1485 Enz. Inhib. hit(s) with Target = 'NAD-dependent protein deacetylase sirtuin-2'
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 68nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 73nMAssay Description:Inhibition of full length human recombinant N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as subs...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 140nMAssay Description:Inhibition of full length human recombinant N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as subs...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 140nMAssay Description:Inhibition of full length human recombinant N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as subs...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Inhibition of full length human recombinant N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as subs...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 470nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 620nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 end residues) expressed in Escherichia coli using tubulin-K40 peptide in prese...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.18E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.22E+3nMAssay Description:Uncompetitive inhibition of human N-terminal His6-SUMO-tagged SIRT2 catalytic domain (43 to 356 residues) deacetylase activity expressed in Escherich...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.28E+3nMAssay Description:Non-competitive inhibition of human recombinant SIRT2 using Z-QPK(Me)2K(Ac) as substrate assessed as decrease in maximal enzyme activity preincubated...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 3.70E+3nMAssay Description:Non-competitive inhibition of human recombinant SIRT2 using Z-QPK(Me)2K(Ac) as substrate assessed as decrease in maximal enzyme activity preincubated...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 5.30E+3nMAssay Description:Competitive inhibition of human SIRT2 assessed as deacetylation activity using fluorescent peptide substrate in presence of NAD+ by Lineweaver-Burk p...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 7.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 7.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 9.80E+3nMAssay Description:Noncompetitive inhibition of human SIRT2 assessed as deacetylation activity using fluorescent substrate in presence of NAD+ by Lineweaver-Burk plot a...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 1.10E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 1.20E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 1.30E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.60E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.70E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.80E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.89E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 3.10E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 5.40E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 5.40E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 5.60E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 8.70E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 8.80E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 9.20E+4nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 1.11E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.72E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataKi: 2.86E+5nMAssay Description:Inhibition of human recombinant SIRT2 assessed as inhibition of substrate deacetylation using Gln-Pro-Lys-Lys- (epsilon acetyl) AMC peptide as substr...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Kyoto Prefectural University of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair