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Report error Found 1967 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase/endoribonuclease IRE1'
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547871(CHEMBL4757194)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547872(CHEMBL4777304)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547873(CHEMBL4789787)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547870(CHEMBL4798215)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547874(CHEMBL4748828)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547869(CHEMBL4790916)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human His-tagged IRE1alpha expressed in Sf9 insect cells preincubated for 1 hr followed by Alexa fluor 647-labeled probe addition and m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM602924(1-(4-(8-amino-3-isopropyl-5-(4-(methylamino)cycloh...)
Affinity DataIC50:  1nMAssay Description:The kinase reactions were performed in 384 well white ProxiPlate-384 Plus plates (PERKIN Elmer 6008280) using 25 mM MOPS assay buffer with 1 mM dithi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM602926(1-(4-(8-amino-3-isopropyl-5-(4-(methylamino)cycloh...)
Affinity DataIC50:  1nMAssay Description:The kinase reactions were performed in 384 well white ProxiPlate-384 Plus plates (PERKIN Elmer 6008280) using 25 mM MOPS assay buffer with 1 mM dithi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM602927(1-(4-(8-amino-3-isopropyl-5-(4-(methylamino)cycloh...)
Affinity DataIC50:  1nMAssay Description:The kinase reactions were performed in 384 well white ProxiPlate-384 Plus plates (PERKIN Elmer 6008280) using 25 mM MOPS assay buffer with 1 mM dithi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM602929(1-(4-(8-amino-3-isopropyl-5-(4-(methylamino)cycloh...)
Affinity DataIC50:  1nMAssay Description:The kinase reactions were performed in 384 well white ProxiPlate-384 Plus plates (PERKIN Elmer 6008280) using 25 mM MOPS assay buffer with 1 mM dithi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662027(2-chloro-N-(4-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662028(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662029(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662030(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662031(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662032(2-chloro-N-(5-(2-(2-(((1r,4r)-4- (dimethylamino)cy...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662033(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662034(4-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662036(2-chloro-N-(6-methyl-5-(2-(2-(((1r,4r)-4- (methyla...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662037(N-(5-(2-(2-((1r,4r)-4- aminocyclohexyl)amino)pyrim...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662038(N-(5-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662039(2-chloro-N-(6-ethyl-5-((E)-2-(2-(((1r,4r)-4- (meth...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662040(2-chloro-N-(6-methoxy-5-((E)-2-(2-(((1r,4r)- 4- (m...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662041((E)-N-(5-(2-(2-((4-aminobicyclo[2.2.2]octan- 1-yl)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662042(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662043(2,3-dichloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethyl...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662044(2-chloro-N-(6-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662031(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662046(N-(5-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662047(2-chloro-N-(4-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662048(4-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662049(2-chloro-N-(6-methoxy-5-((E)-2-(2-(((1r,4r)- 4-mor...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662050(N-(5-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662051(2-chloro-N-(3-fluoro-6-methoxy-5-((E)-2-(2- (((1r,...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662052(2-chloro-N-(6-methoxy-5-((E)-2-(2-(((1r,4r)- 4-(pi...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662053(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662054(4-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662055(2,3-dichloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethyl...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662056(2-chloro-N-(6-methoxy-5-((E)-2-(2-(((1r,4r)- 4- th...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662057(4-chloro-N-(4-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662058(2-chloro-N-(4-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662059(2-chloro-N-(4-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662060(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM661995(N-(4-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM661994(N-(6-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM661997(N-(4-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM661998(N-(4-(2-(2-(((1r,4r)-4- aminocyclohexyl)amino)pyri...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662000(N-(4-(2-(2-(((1r,4r)-4- aminocyclohexyl)amino)pyri...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662001(N-(5-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM662002(N-(5-(2-(2-(((1r,4r)-4- aminocyclohexyl)amino)pyri...)
Affinity DataIC50: <1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
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