Compile Data Set for Download or QSAR
maximum 50k data
Found 190 of ki for UniProtKB: P18825
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213212(CHEMBL50390)
Affinity DataKi:  0.25nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052882(AGN-193080 | CHEMBL298936 | Imidazolidin-2-ylidene...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052880(CHEMBL49137 | Imidazolidin-2-ylidene-(5-methyl-qui...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052880(CHEMBL49137 | Imidazolidin-2-ylidene-(5-methyl-qui...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]RX821002 from alpha-2 adrenergic receptor in human brain pre-frontal cortex neural membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM34572(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to alpha2 adrenoceptor in human cortical membraneMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50476638(CHEMBL75389)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM34572(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM34572(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor of HT-29 cellsMore data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213214(CHEMBL42139)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  5nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50029050((-)-(R)-epinephrine | (-)-3,4-dihydroxy-alpha-((me...)
Affinity DataKi:  5nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213211(CHEMBL50769)
Affinity DataKi:  5.20nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213028(CHEMBL74283)
Affinity DataKi:  6nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225305(CHEMBL433730)
Affinity DataKi:  6.10nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225327(CHEMBL31062)
Affinity DataKi:  7nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity towards human alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213213(CHEMBL50430)
Affinity DataKi:  7.80nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  9nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225302(CHEMBL433083)
Affinity DataKi:  11nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019061((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Affinity DataKi:  12nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225343(CHEMBL31195)
Affinity DataKi:  15nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM66983(6-chloranyl-3-methyl-1,2,4,5-tetrahydro-3-benzazep...)
Affinity DataKi:  17nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225303(CHEMBL52069)
Affinity DataKi:  18nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50476634(4,4''-Di(2-Imidazolidinylimino)Diphenyl Sulfide | ...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225334(CHEMBL281064)
Affinity DataKi:  25nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50029051((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Affinity DataKi:  30nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50270852(CHEMBL4125770)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in human brain prefrontal cortex membranes after 30 mins by microbeta liquid scintillati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213216(CHEMBL883)
Affinity DataKi:  41nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213029(CHEMBL49395)
Affinity DataKi:  41nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50479675(CHEMBL473567)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213027(CHEMBL342029)
Affinity DataKi:  46nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50225307(CHEMBL170660)
Affinity DataKi:  48nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from four to five separate experiments usi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019848(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50179393(Efaroxan)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-RX 821002 from Alpha-2 adrenergic receptors of rabbit white fat cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019848(2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50479673(CHEMBL467525)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50476630(CHEMBL242102)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50213029(CHEMBL49395)
Affinity DataKi:  64nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  66nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50070099(CHEMBL3408019)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]-RX-821002 from human alpha-2 adrenergic receptor in brain prefrontal cortex membrane by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50050093((4-Chloro-6-methoxy-2-methyl-pyrimidin-5-yl)-imida...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50479674(CHEMBL482359)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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