TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) T790M/L858R mutant expressed in Sf9 cells pre-incubated fo...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) by HTRF assay in presence of Km of ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) by HTRF assay in presence of Km of ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.310nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.380nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.420nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) L858R mutant expressed in Sf9 cells pre-incubated for 30 m...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.630nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.637nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.660nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.677nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.710nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of EGFR L858R/T90M double mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.830nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition for...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 0.970nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human EGFR T790M/L858R double mutant using biotinylated TK substrate incubated for 50 mins by HTRF as...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR Del ex19 mutant phosphorylation in human PC9 cells preincubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) by HTRF assay in presence of 2mM of ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of EGFR tyrosine kinase L858R mutant (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human GST-fused EGFR T790M/C797S double mutant expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L851Q mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of cytoplasmic GST-tagged human recombinant EGFR L858R mutant expressed in baculovirus system by z-lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human EGFR L858R/T790M double mutant assessed as reduction in autophosphorylation of cytoplasmic domain by Z'-Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund
Curated by ChEMBL
Technische Universit£T Dortmund
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair