BindingDB PrimarySearch_ki

Found 31 of ic50 for monomerid = 25036

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astellas Pharma

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astellas Pharma

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by radiometric assayMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astellas Pharma

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK2(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 1.10nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

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Cyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
The University Of Melbourne

Curated by ChEMBL

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 1.40nMAssay Description:Inhibition of recombinant human CDK9/cyclin-T1 using H-YSPTSPSYSPTSPSYSPTSPS-KKKK-OH as substrate after 90 mins by luminescence assayMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 1.40nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 3.40nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 3.70nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The University Of Melbourne

Curated by ChEMBL

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 5.20nMAssay Description:Inhibition of FLT3 (unknown origin) using biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 as substrate after 90 mins b...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astellas Pharma

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 5.80nMAssay Description:Inhibition of PI3K alpha (unknown origin)More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 6.30nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK4(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 6.90nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 7nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Astellas Pharma

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 7.80nMAssay Description:Inhibition of human recombinant p110alphaMore data for this Ligand-Target Pair

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Putative glycogen synthase kinase 3 alpha(Ustilago maydis (Smut fungus))
Technische UniversitÄT Dortmund

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 8nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Technische UniversitÄT Dortmund

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 10nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 10nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK3(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 12nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

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Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Technische UniversitÄT Dortmund

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 18nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair

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3D Structure (crystal)

Dual specificity protein kinase CLK1(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 19nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair

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Platelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 25nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair

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Dual specificity protein kinase CLK1(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 31nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells using myelin basic protein as substrate incubated for 110 mins in presence of ATP ...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Astellas Pharma

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 40nMpH: 7.4 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair

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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
Astellas Pharma

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 100nMpH: 7.4 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 118nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 340nMAssay Description:Inhibition of human recombinant p110betaMore data for this Ligand-Target Pair

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Maternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 400nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair

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Casein kinase I isoform epsilon(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 405nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 850nMpH: 7.4 T: 2°CAssay Description:The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...More data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 910nMAssay Description:Inhibition of human recombinant p110deltaMore data for this Ligand-Target Pair

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Dual specificity tyrosine-phosphorylation-regulated kinase 4(Homo sapiens (Human))TBA

PNG

BDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)

IC50: 2.59E+3nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair

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Filter my 31 hits

Targets 22▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5
- Dual specificity protein kinase CLK1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Glycogen synthase kinase-3 beta 2
- Receptor-type tyrosine-protein kinase FLT3 1
- Platelet-derived growth factor receptor alpha/beta 1
- Putative glycogen synthase kinase 3 alpha 1
- Cyclin-dependent kinase 9 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- Maternal embryonic leucine zipper kinase 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 4 1
- Casein kinase I isoform epsilon 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
Publications 7▿
- Bioorg Med Chem 15: 5837-44 (2007) 4
- Bioorg Med Chem 23: 6280-96 (2015) 3
- Bioorg Med Chem 15: 7677-87 (2007) 3
- J Med Chem 59: 8667-8684 (2016) 2
- ACS Chem Biol 7: 1257-67 (2012) 2
- US Patent US10981896 (2021) 1
- J Med Chem 65: 893-921 (2022) 1
Institutions 7▿
- Astellas Pharma 4
- University Of Auckland 3
- The University Of Melbourne 3
- Technische UniversitÄT Dortmund 2
- University Of Nebraska Medical Center 2
- Csir-Indian Institute Of Integrative Medicine 1
- Board of Regents, The University of Texas System 1
Affinity: 0.30 to 2.6E+3 nM▿
- IC50 31
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1