Compile Data Set for Download or QSAR
Found 2 of ic50 for monomerid = 284982
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM284982(N-benzyl-3-(2-methyl-1-oxoisoquinolin-4-yl) benzen...)
Show SMILES Cn1cc(-c2cccc(c2)S(=O)(=O)NCc2ccccc2)c2ccccc2c1=O
Show InChI InChI=1S/C23H20N2O3S/c1-25-16-22(20-12-5-6-13-21(20)23(25)26)18-10-7-11-19(14-18)29(27,28)24-15-17-8-3-2-4-9-17/h2-14,16,24H,15H2,1H3
Affinity DataIC50: 2.75E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM284982(N-benzyl-3-(2-methyl-1-oxoisoquinolin-4-yl) benzen...)
Show SMILES Cn1cc(-c2cccc(c2)S(=O)(=O)NCc2ccccc2)c2ccccc2c1=O
Show InChI InChI=1S/C23H20N2O3S/c1-25-16-22(20-12-5-6-13-21(20)23(25)26)18-10-7-11-19(14-18)29(27,28)24-15-17-8-3-2-4-9-17/h2-14,16,24H,15H2,1H3
Affinity DataIC50: 2.99E+3nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid