Compile Data Set for Download or QSAR
Found 3 of ic50 for monomerid = 285025
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM285025(2-methyl-4-pyridin-2-ylisoquinolin-1-one | US10023...)
Show SMILES Cn1cc(-c2ccccn2)c2ccccc2c1=O
Show InChI InChI=1S/C15H12N2O/c1-17-10-13(14-8-4-5-9-16-14)11-6-2-3-7-12(11)15(17)18/h2-10H,1H3
Affinity DataIC50: 5.00E+3nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM285025(2-methyl-4-pyridin-2-ylisoquinolin-1-one | US10023...)
Show SMILES Cn1cc(-c2ccccn2)c2ccccc2c1=O
Show InChI InChI=1S/C15H12N2O/c1-17-10-13(14-8-4-5-9-16-14)11-6-2-3-7-12(11)15(17)18/h2-10H,1H3
Affinity DataIC50: 5.00E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research Inc

US Patent
LigandPNGBDBM285025(2-methyl-4-pyridin-2-ylisoquinolin-1-one | US10023...)
Show SMILES Cn1cc(-c2ccccn2)c2ccccc2c1=O
Show InChI InChI=1S/C15H12N2O/c1-17-10-13(14-8-4-5-9-16-14)11-6-2-3-7-12(11)15(17)18/h2-10H,1H3
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid