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Found 4 of ic50 for monomerid = 291455
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291455(N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50:  9.90nMAssay Description:Covalent inhibition of N-terminal GST-fused human BTK (2-659(end) amino acids) expressed in baculovirus expression system using FITC-AHA-EEPLYWSFPAKK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291455(N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50:  70nMAssay Description:Inhibition of BTK in human PBMC cells assessed as reduction in anti-IgM-stimulated CD69 expression on B cells preincubated for 60 mins followed by go...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291455(N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM291455(N-(4-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)a...)
Affinity DataIC50: <100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent