Compile Data Set for Download or QSAR
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Found 9 of ic50 for monomerid = 312261
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  24nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  24nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  24nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  31nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of MPO in human HL-60 cells measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  3.80E+4nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  3.80E+4nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  3.80E+4nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent