BindingDB PrimarySearch

Found 19 of ic50 for monomerid = 50092079

BDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 1nMAssay Description:Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

NT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 1nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

High affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 3nMAssay Description:Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 600nMAssay Description:Inhibition of Tel-fused ROS (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 5.50E+3nMAssay Description:Inhibition of Tel-fused KIT (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

ALK tyrosine kinase receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 6.30E+3nMAssay Description:Inhibition of NMP-fused ALK (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 6.40E+3nMAssay Description:Inhibition of Tel-fused LYN (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 6.50E+3nMAssay Description:Inhibition of Tel-fused KDR (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase receptor Tie-1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 6.50E+3nMAssay Description:Inhibition of Tel-fused TIE1 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 6.70E+3nMAssay Description:Inhibition of Tel-fused JAK2 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Hepatocyte growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 7.70E+3nMAssay Description:Inhibition of Tel-fused MET (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 8.00E+3nMAssay Description:Inhibition of Tel-fused RET (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 8.10E+3nMAssay Description:Inhibition of Tel-fused FLT3 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase Fgr(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 8.70E+3nMAssay Description:Inhibition of Tel-fused FGR (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Insulin receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 8.80E+3nMAssay Description:Inhibition of Tel-fused INSR (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Fibroblast growth factor receptor 4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 9.20E+3nMAssay Description:Inhibition of Tel-fused FGFR4 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinan...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Fibroblast growth factor receptor 3(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: 9.50E+3nMAssay Description:Inhibition of Tel-fused FGFR3 (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinan...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: >1.00E+4nMAssay Description:Inhibition of Tel-fused FMS (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Cytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL

BDBM50092079(CHEMBL3582439)

IC50: >1.00E+4nMAssay Description:Inhibition of Tel-fused BMX (unknown origin) expressed in mouse BA/F3 cells after 48 hrs by luciferase reporter gene assay in absence of recombinant ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Filter my 19 hits

Targets 19▿
- Receptor-type tyrosine-protein kinase FLT3 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Tyrosine-protein kinase receptor Tie-1 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- NT-3 growth factor receptor 1
- High affinity nerve growth factor receptor 1
- Macrophage colony-stimulating factor 1 receptor 1
- Tyrosine-protein kinase Lyn 1
- Mast/stem cell growth factor receptor Kit 1
- Tyrosine-protein kinase JAK2 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- ALK tyrosine kinase receptor 1
- Hepatocyte growth factor receptor 1
- Fibroblast growth factor receptor 4 1
- BDNF/NT-3 growth factors receptor 1
- Insulin receptor 1
- Tyrosine-protein kinase Fgr 1
- Vascular endothelial growth factor receptor 2 1
- Fibroblast growth factor receptor 3 1
Publications 1▿
- ACS Med Chem Lett 6: 562-7 (2015) 19
Institutions 1▿
- Genomics Institute Of The Novartis Research Foundation 19
Affinity: 1 to 1.0E+4 nM▿
- IC50 19
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0