Compile Data Set for Download or QSAR
maximum 50k data
Found 9 of ic50 for monomerid = 50146654
TargetEndothelin-1 receptor(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50:  12.3nMAssay Description:Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]-ET-1 as ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50:  184nMAssay Description:Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]-ET-1 as ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50:  184nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50:  184nMAssay Description:Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146654((S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed