BindingDB PrimarySearch

Found 13 of ic50 for monomerid = 50357803

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: 0.700nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: 108nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

Adenosine receptor A1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: 150nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >5.00E+3nMAssay Description:Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >5.00E+3nMAssay Description:Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

Adenosine receptor A2a(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: 5.05E+3nMAssay Description:Inhibition of adenosine A2A receptorMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50357803(CHEMBL1916113)

IC50: >1.00E+5nMAssay Description:Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid PDB Patents Similars

Details Article PubMed

Filter my 13 hits

Targets 13▿
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1
- Adenosine receptor A1 1
- Adenosine receptor A2a 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 1▿
- J Med Chem 54: 7621-38 (2011) 13
Institutions 1▿
- Pfizer 13
Affinity: 0.70 to 1.0E+5 nM▿
- IC50 13
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0