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Found 6 of ic50 for monomerid = 50371228
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50:  4nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50:  9.03E+3nMAssay Description:Inhibition of Holtzman-Sprague-Dawley rat liver HMG CoA reductase after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50:  2.68E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50:  5.83E+4nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371228(Crestor | ROSUVASTATIN CALCIUM | Rosuvastatin | US...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed