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Cytochrome P450 2D6(Homo sapiens (Human))
Lupin

Curated by ChEMBL

PNG

BDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)

IC50: 78nMAssay Description:Inhibition of CYP2D6 in pooled human liver microsomes pre-incubated for 5 mins before NADPH addition and measured after 10 mins by UPLC-MS/MS analysi...More data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 253 hits

Targets 18▿
- Sodium channel protein type 9 subunit alpha 83
- Nonstructural protein 5A 63
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 29
- Interleukin-2 19
- Sodium channel protein type 5 subunit alpha 15
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 13
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 9
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 8
- Calcium release-activated calcium channel protein/Stromal interaction molecule 1 4
- Neuronal acetylcholine receptor subunit alpha-7 2
- Protein orai-2/Stromal interaction molecule 1 1
- Protein orai-3/Stromal interaction molecule 1 1
- Sodium channel protein type 2 subunit alpha 1
- Tumor necrosis factor 1
- Cytochrome P450 2C9 1
- Cytochrome P450 2D6 1
- Potassium voltage-gated channel subfamily H member 2 1
- Cytochrome P450 3A4 1
- ...
Publications 5▿
- J Med Chem 63: 6107-6133 (2020) 99
- J Med Chem 62: 10563-10582 (2019) 66
- J Med Chem 63: 14700-14723 (2020) 59
- J Med Chem 64: 17004-17030 (2021) 27
- J Med Chem 63: 944-960 (2020) 2
Institutions 1▿
- Lupin 253
Affinity: 0.0030 to 1.0E+4 nM▿
- IC50 251
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 14