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Found 11 with your filter

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358203(CHEMBL1922093)

IC50: 10nMAssay Description:Inhibition of PI3K subunit p110gamma assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)

IC50: 15nMAssay Description:Inhibition of PI3Kgamma using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50315907(5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)m...)

IC50: 15nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358205(CHEMBL1922090)

IC50: 17nMAssay Description:Inhibition of PI3K subunit p110gamma assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358207(CHEMBL1922092)

IC50: 20nMAssay Description:Inhibition of PI3K subunit p110gamma assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358209(CHEMBL1922095)

IC50: 25nMAssay Description:Inhibition of PI3K subunit p110gamma assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358208(CHEMBL1921986)

IC50: 33nMAssay Description:Inhibition of PI3K subunit p110gamma assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358204(CHEMBL1922094)

IC50: 36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358204(CHEMBL1922094)

IC50: 36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM50358206(CHEMBL1922091)

IC50: 37nMAssay Description:Inhibition of PI3K subunit p110gamma assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

BDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)

IC50: 66nMAssay Description:Inhibition of PI3Kgamma using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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PDB

3D Structure (crystal)

Filter my 1289 hits

Targets 35▿
- Nicotinamide phosphoribosyltransferase 596
- Leucine-rich repeat serine/threonine-protein kinase 2 275
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 54
- Cytochrome P450 2C9 52
- Serine/threonine-protein kinase B-raf 43
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 41
- Voltage-dependent calcium channel subunit alpha-2/delta-1 34
- Sonic hedgehog protein 31
- Serine/threonine-protein kinase mTOR 20
- Tyrosine-protein kinase JAK2 14
- Cytochrome P450 1A2 13
- Cytochrome P450 2C19 13
- Cytochrome P450 2D6 13
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 11
- Histone deacetylase 2 10
- Histone deacetylase 1 10
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 9
- Polyamine deacetylase HDAC10 5
- Histone deacetylase 8 5
- Histone deacetylase 9 5
- Histone deacetylase 6 5
- Histone deacetylase 7 5
- Histone deacetylase 4 5
- Histone deacetylase 5 5
- Histone deacetylase 3 5
- Tyrosine-protein kinase SYK 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Mitogen-activated protein kinase kinase kinase 9 1
- Phosphatidylinositol 4-kinase alpha 1
- Dual specificity protein kinase TTK 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Tyrosine-protein kinase Fgr 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1
- ...
Publications 16▿
- US Patent US10696692 (2020) 374
- US Patent US8802674 (2014) 212
- J Med Chem 57: 770-92 (2014) 96
- Bioorg Med Chem Lett 23: 3531-8 (2013) 81
- J Med Chem 56: 4921-37 (2013) 74
- J Med Chem 54: 7815-33 (2011) 70
- J Med Chem 56: 6413-33 (2013) 60
- J Biol Chem 288: 26926-43 (2013) 60
- J Med Chem 55: 9416-33 (2012) 49
- J Med Chem 54: 7579-87 (2011) 48
- ACS Med Chem Lett 2: 342-7 (2011) 42
- Bioorg Med Chem Lett 14: 2463-7 (2004) 34
- Bioorg Med Chem Lett 19: 5576-81 (2009) 32
- J Med Chem 55: 5536-45 (2012) 29
- Bioorg Med Chem Lett 20: 2408-11 (2010) 25
- J Med Chem 55: 2869-81 (2012) 3
Institutions 5▿
- Genentech 705
- TBA 374
- Forma Therapeutics 134
- Array Biopharma 42
- Merck Research Laboratories 34
Affinity: 0.40 to 5.0E+5 nM▿
- Ki 341
- IC50 931
- Kd 17
- Affinity ≤ nM
Xtal structures: 21
Docked structures: 2
Catalog Cmpds: 35