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TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054498((R)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  0.700nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054493(CHEMBL343805 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  0.710nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093056((S)-N-Benzo[1,3]dioxol-5-ylmethyl-4-cyclohexyl-3-{...)
Affinity DataIC50:  0.780nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093057((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  0.860nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054492((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  1.10nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054494(2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohex...)
Affinity DataIC50:  1.12nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054492((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  1.36nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054498((R)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  1.52nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093062((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093066(((S)-4-Cyclohexyl-3-{2-[((R)-5-guanidino-2-phenylm...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093061((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093057((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  3.40nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against prothrombinase (PTase) complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054502(CHEMBL140494 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  6.20nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093058(((S)-3-{2-[((R)-5-Guanidino-2-phenylmethanesulfony...)
Affinity DataIC50:  6.60nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093060(CHEMBL432159 | [(S)-3-{2-[((R)-5-Guanidino-2-pheny...)
Affinity DataIC50:  7.60nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093065((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  7.90nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against prothrombinase (PTase) complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093056((S)-N-Benzo[1,3]dioxol-5-ylmethyl-4-cyclohexyl-3-{...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093063((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054504(2-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl)-N...)
Affinity DataIC50:  14.2nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054504(2-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl)-N...)
Affinity DataIC50:  16.6nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054493(CHEMBL343805 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  20.6nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093058(((S)-3-{2-[((R)-5-Guanidino-2-phenylmethanesulfony...)
Affinity DataIC50:  25nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against prothrombinase (PTase) complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093065((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  26nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against prothrombinase (PTase) complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093060(CHEMBL432159 | [(S)-3-{2-[((R)-5-Guanidino-2-pheny...)
Affinity DataIC50:  29nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against prothrombinase (PTase) complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093064((R)-5-Nitro-Guanidino-2-phenylmethanesulfonylamino...)
Affinity DataIC50:  46nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054493(CHEMBL343805 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  74.5nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093057((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  75nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against Human trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054503(CHEMBL263924 | N-((1S,2R)-3-Carbamimidoyl-2-hydrox...)
Affinity DataIC50:  111nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054505(CHEMBL421760 | N-(3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  125nMAssay Description:compound was tested in vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054494(2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohex...)
Affinity DataIC50:  137nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054495(CHEMBL422470 | Lactum Sulfonamide analogue)
Affinity DataIC50:  147nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054489(CHEMBL139656 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  157nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054491(2-((S)-3-Benzenesulfonylamino-2-oxo-piperidin-1-yl...)
Affinity DataIC50:  159nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093062((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  163nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against Human trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054495(CHEMBL422470 | Lactum Sulfonamide analogue)
Affinity DataIC50:  235nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093059(((S)-4-(4-tert-Butoxy-phenyl)-3-{2-[((R)-5-guanidi...)
Affinity DataIC50:  246nMAssay Description:Inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054499(CHEMBL334454 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  286nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054492((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  290nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054499(CHEMBL334454 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  293nMAssay Description:compound was tested in vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054490(CHEMBL138243 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  420nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054489(CHEMBL139656 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  467nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054494(2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohex...)
Affinity DataIC50:  471nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054504(2-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl)-N...)
Affinity DataIC50:  479nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054505(CHEMBL421760 | N-(3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  538nMAssay Description:compound was tested in vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054501(2-[(S)-3-(Butane-1-sulfonylamino)-2-oxo-piperidin-...)
Affinity DataIC50:  709nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054491(2-((S)-3-Benzenesulfonylamino-2-oxo-piperidin-1-yl...)
Affinity DataIC50:  770nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054502(CHEMBL140494 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  791nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054503(CHEMBL263924 | N-((1S,2R)-3-Carbamimidoyl-2-hydrox...)
Affinity DataIC50:  1.02E+3nMAssay Description:compound was tested in vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054491(2-((S)-3-Benzenesulfonylamino-2-oxo-piperidin-1-yl...)
Affinity DataIC50:  1.10E+3nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50093057((R)-5-Guanidino-2-phenylmethanesulfonylamino-penta...)
Affinity DataIC50:  1.20E+3nMAssay Description:Compound was evaluated in vitro for its inhibitory activity against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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