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Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataIC50:  0.0900nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in xenopus oocytes assessed as inhibition of 5HT-induced effect by electrophysiological methodMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM85330(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Affinity DataIC50:  0.160nMAssay Description:Binding affinity to rat 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  0.180nMAssay Description:Binding affinity to rat 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Affinity DataIC50:  3.17nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400901(CHEMBL2204361)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400889(CHEMBL2204357)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400893(CHEMBL2205053)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400903(CHEMBL2204359)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  5.40nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400892(CHEMBL2205054)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400879(CHEMBL2205046)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400904(CHEMBL2204358)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400888(CHEMBL2205037)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400883(CHEMBL2205042)
Affinity DataIC50:  8nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400887(CHEMBL2205038)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400899(CHEMBL2204363)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400900(CHEMBL2204362)
Affinity DataIC50:  11nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human 5HT3A receptor expressed in xenopus oocytes assessed as inhibition of 5HT-induced effect by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400882(CHEMBL2205043)
Affinity DataIC50:  13nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400894(CHEMBL2205052)
Affinity DataIC50:  15nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50:  17nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400880(CHEMBL2205045)
Affinity DataIC50:  18nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400885(CHEMBL2205040)
Affinity DataIC50:  20nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400890(CHEMBL2204356)
Affinity DataIC50:  21nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400910(CHEMBL2204365)
Affinity DataIC50:  25nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400891(CHEMBL2204355)
Affinity DataIC50:  37nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400882(CHEMBL2205043)
Affinity DataIC50:  37nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400911(CHEMBL2204364)
Affinity DataIC50:  44nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400882(CHEMBL2205043)
Affinity DataIC50:  45nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400895(CHEMBL2205051)
Affinity DataIC50:  51nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400898(CHEMBL2205048)
Affinity DataIC50:  53nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400897(CHEMBL2205049)
Affinity DataIC50:  54nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400881(CHEMBL2205044)
Affinity DataIC50:  67nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400886(CHEMBL2205039)
Affinity DataIC50:  68nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  74nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  74nMAssay Description:Inhibition of [3H]5-HT uptake at SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400880(CHEMBL2205045)
Affinity DataIC50:  110nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400892(CHEMBL2205054)
Affinity DataIC50:  120nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400906(CHEMBL2205034)
Affinity DataIC50:  130nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400877(CHEMBL2205036)
Affinity DataIC50:  150nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400889(CHEMBL2204357)
Affinity DataIC50:  170nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50024209((+/-)2-(4-Methoxy-phenyl)-1-methyl-ethylamine | (-...)
Affinity DataIC50:  173nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50029100(2-(4-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL35...)
Affinity DataIC50:  182nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400909(CHEMBL2205031)
Affinity DataIC50:  200nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50029100(2-(4-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL35...)
Affinity DataIC50:  207nMAssay Description:Inhibition of human noradrenaline transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  207nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50400905(CHEMBL2205035)
Affinity DataIC50:  250nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50400903(CHEMBL2204359)
Affinity DataIC50:  250nMAssay Description:Inhibition of DAT-mediated [3H]DA in rat synaptomsomes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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