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TargetGlucocorticoid receptor(Rat)
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50265673(CHEMBL4068611)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat glucocorticoid receptor in primary hepatocytes assessed as induction of tyrosine amino transferase activity measured after 20...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Dog)
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50265673(CHEMBL4068611)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at dog glucocorticoid receptor in primary hepatocytes assessed as induction of tyrosine amino transferase activity measured after 20...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  501nMAssay Description:Binding affinity to PI3Kgamma in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  158nMAssay Description:Binding affinity to PI3Kalpha in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  50nMAssay Description:Binding affinity to PI3Kbeta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  2.51E+3nMAssay Description:Binding affinity to PI3Kgamma in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  158nMAssay Description:Binding affinity to PI3Kbeta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataKd:  63nMAssay Description:Binding affinity to VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  2nMAssay Description:Binding affinity to VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  316nMAssay Description:Binding affinity to PI3Kalpha in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataKd:  0.251nMAssay Description:Binding affinity to PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50543032(CHEMBL4645570)
Affinity DataKd:  251nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) by SPR based van't Hoff analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50543037(CHEMBL4638471)
Affinity DataKd:  4nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) by SPR based van't Hoff analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50573153(CHEMBL4877995)
Affinity DataIC50: 0nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573157(CHEMBL4850297)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573166(CHEMBL4869783)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506311(CHEMBL4462123)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573177(CHEMBL4167702)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573181(CHEMBL4165185)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573180(CHEMBL4175737)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573164(CHEMBL4873390)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573174(CHEMBL4868232)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573175(CHEMBL4169192)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506329(CHEMBL4518946)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506329(CHEMBL4518946)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506332(CHEMBL4561242)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573176(CHEMBL4173087)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573178(CHEMBL4170075)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573179(CHEMBL4174874)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573155(CHEMBL4872328)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kdelta in human HL-60 cell extract measured after 2 hrs by kinobeads based chemoproteomic competition binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50506325(CHEMBL4567736)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573163(CHEMBL4870020)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573170(CHEMBL4855234)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506328(CHEMBL4447804)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506333(CHEMBL4553962)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506346(CHEMBL4436659)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506327(CHEMBL4449047)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506327(CHEMBL4449047)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506320(CHEMBL4436797)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573158(CHEMBL4869356)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573159(CHEMBL4867203)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573168(CHEMBL4845674)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573173(CHEMBL4870970)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573176(CHEMBL4173087)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50573178(CHEMBL4170075)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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