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Found 128 with Last Name = 'bowers' and Initial = 'kc'
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414304(CHEMBL550030)
Affinity DataIC50:  0.0501nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414307(CHEMBL560506)
Affinity DataIC50:  0.0794nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414305(CHEMBL551360)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414314(CHEMBL564882)
Affinity DataIC50:  0.316nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414309(CHEMBL551362)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414306(CHEMBL556680)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126727((S)-4-(3-(4-(4-fluorophenyl)piperazin-1-yl)-2-(N-m...)
Affinity DataIC50:  1.26nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414350(CHEMBL550436)
Affinity DataIC50:  1.26nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414313(CHEMBL560219)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414312(CHEMBL552513)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414311(CHEMBL552512)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414303(CHEMBL560563)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414349(CHEMBL564535)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414330(CHEMBL563379)
Affinity DataIC50:  6.31nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126705((S)-4-(3-(4-(4-fluorophenyl)piperazin-1-yl)-2-(iso...)
Affinity DataIC50:  6.31nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414310(CHEMBL563255)
Affinity DataIC50:  6.31nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414282(CHEMBL551301)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414302(CHEMBL560616)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414331(CHEMBL551377)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50412149(CHEMBL497967)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414283(CHEMBL562308)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414301(CHEMBL563152)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50352058(CHEMBL560241)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414339(CHEMBL180397)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human U373 cells assessed as inhibition of BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411881(CHEMBL271462)
Affinity DataIC50:  12.6nMAssay Description:Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50410956(CHEMBL437703)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50410949(CHEMBL210835)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human lymphocytes assessed as inhibition of ATP-induced Ba2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126723((S)-4-(3-(4-(3-chlorophenyl)piperazin-1-yl)-2-(N-m...)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50216395(CHEMBL231032 | N-(2-(4-(2-fluorophenyl)piperazin-1...)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411885(CHEMBL257045)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414348(CHEMBL540946 | KN-04)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human lymphocytes assessed as inhibition of ATP-induced Ba2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414308(CHEMBL563569)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414285(CHEMBL564366)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50410957(CHEMBL380239)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414280(CHEMBL560048)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411881(CHEMBL271462)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414287(CHEMBL555561)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126718((S)-4-(3-(4-(2-chlorophenyl)piperazin-1-yl)-2-(N-m...)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126720((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411877(CHEMBL270678)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126719((S)-4-(3-(4-benzylpiperazin-1-yl)-2-(N-methylisoqu...)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50216402(CHEMBL230925 | N-(2-(4-(4-nitrophenyl)piperazin-1-...)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411902(CHEMBL403222)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414284(CHEMBL549620)
Affinity DataIC50:  19.9nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50234965(A-740003 | CHEMBL255787 | N-(1-(2-cyano-3-(quinoli...)
Affinity DataIC50:  19.9nMAssay Description:Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414315(CHEMBL565027)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411885(CHEMBL257045)
Affinity DataIC50:  25.1nMAssay Description:Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414290(CHEMBL555033)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414289(CHEMBL551707)
Affinity DataIC50:  25.1nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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