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Found 1437 with Last Name = 'cecere' and Initial = 'g'
TargetIntegrin alpha-5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM10484(US11091471, Example RO-301 | US8846719, 301)
Affinity DataKi:  0.200nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM513334(US11091471, Example RE-B)
Affinity DataKi:  0.400nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM513240(6-((5-methyl-3-(6-methylpyridazin-3-yl)isoxazol-4-...)
Affinity DataKi:  0.400nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643722((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390718((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  0.5nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390701((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  0.600nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643732((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-1,4-dimet...)
Affinity DataKi:  0.600nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643717((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643728((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643720((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643750((4S)-7-chloro-6-(2,6-difluorophenyl)-8-iodo-1,4-di...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM513241(N-((1S)-1-(hydroxymethyl)butyl)-6-((5-methyl-3-(6-...)
Affinity DataKi:  0.800nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390723((S)-6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8...)
Affinity DataKi:  0.800nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM283758(N-(4-(azetidin-3-ylidenemethyl)-3,5-difluorophenyl...)
Affinity DataKi:  0.900nMpH: 7.4Assay Description:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390716((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  0.900nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390729((R)-N-(3-Aminochroman-7-yl)-1-methyl-5-(thiophen-2...)
Affinity DataKi:  0.900nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390723((S)-6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8...)
Affinity DataKi:  0.900nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390731((R)-N-(3-Aminochroman-7-yl)-3,4-difluorobenzamide ...)
Affinity DataKi:  0.900nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390701((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  1nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390718((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  1nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390716((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  1nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643749(US20240002393, Example 101 | [(4R)-8-bromo-7-chlor...)
Affinity DataKi:  1nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM513325(6-((5-methyl-3-(6-methylpyridazin-3-yl)isoxazol-4-...)
Affinity DataKi:  1nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM133559(US11091471, Example RO-251 | US8846719, 251)
Affinity DataKi:  1nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM133580(US11091471, Example RO-272 | US8846719, 272)
Affinity DataKi:  1nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643718((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.10nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643719((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.10nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM513187(5-methyl-6-((5-methyl-3-(6-methylpyridin-3-yl)isox...)
Affinity DataKi:  1.20nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM360648((R)-1-(2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]i...)
Affinity DataKi:  1.20nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643715((4S)-8-bromo-7-chloro-6-(2-fluorophenyl)-4-methyl-...)
Affinity DataKi:  1.30nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM513040(N-ethyl-6-((5-methyl-3-(6-methyl-3-pyridyl)isoxazo...)
Affinity DataKi:  1.40nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM283759(N-(4-(azetidin-3-ylidenemethyl)-3,5-difluorophenyl...)
Affinity DataKi:  1.40nMpH: 7.4Assay Description:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643736((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.40nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643743((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  1.5nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM362724(N-(4-Chlorophenyl)-6-[(2S)-morpholin-2-yl]pyridin-...)
Affinity DataKi:  1.5nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM283780(1-[4-[(3-fluoroazetidin-3-yl)methyl]phenyl]-3-[4-(...)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM362747(1-(3-Chlorophenyl)-3-[6-[(2S)-morpholin-2-yl]-3-py...)
Affinity DataKi:  1.60nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM283791(1-[4-(azetidin-3-ylidenemethyl)phenyl]-3-[4-(trifl...)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390710((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  1.60nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390713(6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8-tet...)
Affinity DataKi:  1.70nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM362707((RS)—N-(4-Chlorophenyl)-6-morpholin-2-yl-pyri...)
Affinity DataKi:  1.70nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390727((R)-N-(3-Aminochroman-7-yl)-4-(2-methylthiazol-4-y...)
Affinity DataKi:  1.80nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643740((4S)-7-chloro-6-(2,6-difluorophenyl)-1,4-dimethyl-...)
Affinity DataKi:  1.80nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM362708((RS)—N-(4-Bromophenyl)-6-morpholin-2-yl-pyrid...)
Affinity DataKi:  1.80nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390700((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Affinity DataKi:  1.90nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM362726(N-(5-Chloro-2-pyridyl)-6-[(2S)-morpholin-2-yl]pyri...)
Affinity DataKi:  1.90nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643755((4S)-7-chloro-6-(2,6-difluorophenyl)-1-ethyl-4-met...)
Affinity DataKi:  2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM362727(N-(5-Bromo-2-pyridyl)-6-[(2S)-morpholin-2-yl]pyrid...)
Affinity DataKi:  2nMAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, heat ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643726((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM643742((4S)-7,8-dichloro-6-(2,6-difluorophenyl)-4-methyl-...)
Affinity DataKi:  2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
Target InfoGoogleScholar
Ligand Info
In DepthDetails US Patent
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