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Found 1137 with Last Name = 'convery' and Initial = 'm'
LigandPNGBDBM50573166(CHEMBL4869783)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573157(CHEMBL4850297)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573177(CHEMBL4167702)
Affinity DataKi:  0.0126nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
LigandPNGBDBM50573167(CHEMBL4858875)
Affinity DataKi:  0.0158nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573182(CHEMBL4175571)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573181(CHEMBL4165185)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573164(CHEMBL4873390)
Affinity DataKi:  0.0251nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573180(CHEMBL4175737)
Affinity DataKi:  0.0316nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573175(CHEMBL4169192)
Affinity DataKi:  0.0398nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573179(CHEMBL4174874)
Affinity DataKi:  0.0501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573176(CHEMBL4173087)
Affinity DataKi:  0.0501nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50573178(CHEMBL4170075)
Affinity DataKi:  0.0631nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50521218(CHEMBL4434674)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair
LigandPNGBDBM50573170(CHEMBL4855234)
Affinity DataKi:  0.0794nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228930((E)-2-(6-chloro-benzo[b]thiophen-2-yl)-ethenesulfo...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50573159(CHEMBL4867203)
Affinity DataKi:  0.126nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50004529(CHEMBL2216859)
Affinity DataKi:  0.126nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374259(CHEMBL257741)
Affinity DataKi:  0.200nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306153((S)-2-(5-chlorothiophen-2-yl)-N-(1-(3-fluoro-2'-(m...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228676((S)-2-(5-chlorothiophen-2-yl)-N-(1-(4-(2-((dimethy...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228950((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228676((S)-2-(5-chlorothiophen-2-yl)-N-(1-(4-(2-((dimethy...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50338686((R/S)-3-chloro-N-((3S)-1-(1-(methylamino)-2,3-dihy...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of factor 10a activity measured using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374264(CHEMBL257863)
Affinity DataKi:  0.400nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374262(CHEMBL272779)
Affinity DataKi:  0.400nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228954((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374270(CHEMBL271015)
Affinity DataKi:  0.5nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339718((S)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(1,2,3,4-...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339708((S)-2-(5-chlorothiophen-2-yl)-N-(1-(5-fluoro-1,2,3...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50328712((S)-6-chloro-N-(1-(4-(2-((dimethylamino)methyl)-1H...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374263(CHEMBL437097)
Affinity DataKi:  0.600nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228940(6-chloro-N-(1-(4-(2-cyanopyridin-3-yl)-2-fluorophe...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human F10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306143(6-chloro-N-((S)-1-(4-((S)-1-(dimethylamino)ethyl)-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306142(6-chloro-N-((3S)-1-(4-(1-(ethyl(methyl)amino)ethyl...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339713((S)-6-chloro-N-(2-oxo-1-(2,3,4,5-tetrahydro-1H-ben...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339714((S)-3-chloro-N-(2-oxo-1-(2,3,4,5-tetrahydro-1H-ben...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339716((S)-6-chloro-N-(1-(6-fluoro-2,3,4,5-tetrahydro-1H-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306138(CHEMBL604887 | N-((3S)-1-(4-(1-(azetidin-1-yl)ethy...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50374274(CHEMBL403111)
Affinity DataKi:  0.800nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306146((E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1S)-1...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12542((2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfona...)
Affinity DataKi: <1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12541((2S)-N-[2-(carbamoylamino)ethyl]-2-[(3S)-3-{2-[(6-...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339712((S,E)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(2,3,4,...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306146((E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1S)-1...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12543((2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfona...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50339717((S)-2-(5-chlorothiophen-2-yl)-N-(1-(2-methyl-1,2,3...)
Affinity DataKi:  1nMAssay Description:Inhibition of factor 10a using bis-(CBZ-glycylglycly)-L-arginine amide fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12544((2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfona...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12540((2S)-N-(2-aminoethyl)-2-[(3S)-3-{2-[(6-chloronapht...)
Affinity DataKi: <1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM12557(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50306140(6-chloro-N-((3S)-1-(2-fluoro-4-(1-(isopropylamino)...)
Affinity DataKi:  1nMAssay Description:Inhibition of human factor 10a by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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