Compile Data Set for Download or QSAR
maximum 50k data
Found 158 with Last Name = 'ebden' and Initial = 'mr'
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414304(CHEMBL550030)
Affinity DataIC50:  0.0501nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414307(CHEMBL560506)
Affinity DataIC50:  0.0794nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414305(CHEMBL551360)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414314(CHEMBL564882)
Affinity DataIC50:  0.316nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414309(CHEMBL551362)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50371784(CHEMBL446458)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414306(CHEMBL556680)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414350(CHEMBL550436)
Affinity DataIC50:  1.26nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126727((S)-4-(3-(4-(4-fluorophenyl)piperazin-1-yl)-2-(N-m...)
Affinity DataIC50:  1.26nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414313(CHEMBL560219)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065327(CHEMBL3403851)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414312(CHEMBL552513)
Affinity DataIC50:  2.51nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414303(CHEMBL560563)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414311(CHEMBL552512)
Affinity DataIC50:  3.16nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414349(CHEMBL564535)
Affinity DataIC50:  3.98nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065330(CHEMBL3403854)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065326(CHEMBL3403850)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50371783(CHEMBL397237)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065331(CHEMBL3403855)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065324(CHEMBL3403848)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414310(CHEMBL563255)
Affinity DataIC50:  6.31nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414330(CHEMBL563379)
Affinity DataIC50:  6.31nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126705((S)-4-(3-(4-(4-fluorophenyl)piperazin-1-yl)-2-(iso...)
Affinity DataIC50:  6.31nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065328(CHEMBL3403852)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065325(CHEMBL3403849)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065329(CHEMBL3403853)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414302(CHEMBL560616)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414282(CHEMBL551301)
Affinity DataIC50:  7.94nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414283(CHEMBL562308)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414301(CHEMBL563152)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065267(CHEMBL3403840)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50412149(CHEMBL497967)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414331(CHEMBL551377)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414339(CHEMBL180397)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human U373 cells assessed as inhibition of BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50352058(CHEMBL560241)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as effect on BzATP-induced Yo-Pro uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411881(CHEMBL271462)
Affinity DataIC50:  12.6nMAssay Description:Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411885(CHEMBL257045)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50216395(CHEMBL231032 | N-(2-(4-(2-fluorophenyl)piperazin-1...)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126723((S)-4-(3-(4-(3-chlorophenyl)piperazin-1-yl)-2-(N-m...)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human lymphocytes assessed as inhibition of ATP-induced Ba2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50410949(CHEMBL210835)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50410956(CHEMBL437703)
Affinity DataIC50:  12.6nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065256(CHEMBL3403835)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50065323(CHEMBL3403847)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50126718((S)-4-(3-(4-(2-chlorophenyl)piperazin-1-yl)-2-(N-m...)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414285(CHEMBL564366)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414287(CHEMBL555561)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50411881(CHEMBL271462)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50414280(CHEMBL560048)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50410957(CHEMBL380239)
Affinity DataIC50:  15.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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