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TargetMacrophage migration inhibitory factor(Human)
University of California-San Diego

Curated by ChEMBL
LigandPNGBDBM50491189(CHEMBL2375653)
Affinity DataKd:  3.59E+4nMAssay Description:Binding affinity to human recombinant MIF expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor receptor superfamily member 16(Mouse)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50535058(CHEMBL4439582)
Affinity DataEC50:  20nMAssay Description:Activation of p75NTR in mouse hippocampal neurons assessed as increase in cell survival after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTumor necrosis factor receptor superfamily member 16(Mouse)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50535059(CHEMBL4446977)
Affinity DataEC50: <10nMAssay Description:Activation of p75NTR in C57BL/6 mouse brain assessed as suppression of carbachol-mediated persistant firing of entorhinal cortex after 15 mins by cur...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of British Columbia

Curated by ChEMBL
LigandPNGBDBM50005118(3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-h...)
Affinity DataKd:  1.20nMAssay Description:Binding affinity to D2 receptor in rat brain striatal homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130539(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)
Affinity DataEC50:  790nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130544(Benzoic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-metha...)
Affinity DataEC50:  252nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130545(Benzoic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-metha...)
Affinity DataEC50:  2.79E+3nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130548(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)
Affinity DataEC50:  22nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130538(2,2-Dimethyl-propionic acid 3-[3-(4-acetylamino-be...)
Affinity DataEC50:  450nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130546(2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...)
Affinity DataEC50:  40nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130552(Benzoic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-metha...)
Affinity DataEC50:  166nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130551(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)
Affinity DataEC50:  1.70E+3nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50196337(2-((3-(4-hydroxy-3-methoxybenzyl)thioureido)methyl...)
Affinity DataEC50:  1.97nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50196343(2-((3-(4-hydroxy-3-methoxybenzyl)thioureido)methyl...)
Affinity DataEC50:  2.83nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataEC50:  44.8nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130556(Benzoic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-metha...)
Affinity DataEC50:  1.73E+3nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130554(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)
Affinity DataEC50:  1.14E+3nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rat)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50130555(2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...)
Affinity DataEC50:  990nMAssay Description:In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509050(CHEMBL4438309)
Affinity DataEC50: <1nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50552734(CHEMBL4793625)
Affinity DataEC50:  804nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509049(CHEMBL4440744)
Affinity DataEC50:  1.23E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604467(CHEMBL5169574)
Affinity DataEC50:  1.66E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604468(CHEMBL5187032)
Affinity DataEC50:  1.69E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604469(CHEMBL5187131)
Affinity DataEC50:  0.00400nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604470(CHEMBL5194415)
Affinity DataEC50:  4.60E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604471(CHEMBL5176115)
Affinity DataEC50:  6.22E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604472(CHEMBL5205725)
Affinity DataEC50:  6.55E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604473(CHEMBL5205871)
Affinity DataEC50:  9.12E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604474(CHEMBL5197505)
Affinity DataEC50:  1.76E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604475(CHEMBL5199858)
Affinity DataEC50:  2.86E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604476(CHEMBL5173411)
Affinity DataEC50:  2.98E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604477(CHEMBL5185786)
Affinity DataEC50:  3.01E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  3.01E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604478(CHEMBL5192829)
Affinity DataEC50:  3.91E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604479(CHEMBL5200249)
Affinity DataEC50:  4.86E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604480(CHEMBL5196300)
Affinity DataEC50:  5.11E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50511093(CHEMBL4522871)
Affinity DataEC50:  1.02E+5nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataEC50:  0.354nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604481(CHEMBL5174660)
Affinity DataEC50:  1.62nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataEC50:  2nMAssay Description:Activation of STING mediated immune response in human THP-1 cells assessed as induction of IFNbeta secretion measured after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProtein O-GlcNAcase(Human)
Medifron Dbt

US Patent
LigandPNGBDBM50592032(CHEMBL5194370 | US20240018135, Code C-8)
Affinity DataIC50: 0nMAssay Description:Human OGA (recombinant hOGA protein, advanced Protein Technologies corp., Korea) enzyme reaction was performed in a reaction solution containing 25 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 0.0623nMAssay Description:Binding affinity to recombinant human His-tagged STING by measuring fluorescent signals in the presence of d2 labelled STING wild type ligand by HTRF...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159472(US9034921, E114)
Affinity DataIC50: 0.308nMpH: 7.4 T: 2°CAssay Description:For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159516(US9034921, E158 | US9340521, E024)
Affinity DataIC50: 0.366nMpH: 7.4 T: 2°CAssay Description:For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159528(US9034921, E171 | US9340521, E028)
Affinity DataIC50: 0.366nMpH: 7.4 T: 2°CAssay Description:For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159528(US9034921, E171 | US9340521, E028)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells by methyl-alpha-D-glucopyranoside assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159520(US9034921, E162 | US9340521, E026)
Affinity DataIC50: 0.404nMpH: 7.4 T: 2°CAssay Description:For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159387(US9034921, E001 | US9340521, E001)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells by methyl-alpha-D-glucopyranoside assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159458(US9034921, E098)
Affinity DataIC50: 0.454nMpH: 7.4 T: 2°CAssay Description:For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSodium/glucose cotransporter 2(Human)
Green Cross

US Patent
LigandPNGBDBM159529(US9034921, E172)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells by methyl-alpha-D-glucopyranoside assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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