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TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataEC50:  35.6nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20877(CHEMBL183937 | JMC511145 Compound 2 | 3-(1-benzofu...)
Affinity DataEC50:  6.60nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50:  9.20nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20879(CHEMBL429911 | N-ethyl-2,6-dihydroxy-5-[(4-methoxy...)
Affinity DataEC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataEC50:  1.10nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataEC50:  330nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20877(CHEMBL183937 | JMC511145 Compound 2 | 3-(1-benzofu...)
Affinity DataEC50:  211nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataEC50: >8.00E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20879(CHEMBL429911 | N-ethyl-2,6-dihydroxy-5-[(4-methoxy...)
Affinity DataEC50: >8.00E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Bristol-Myers Squibb

LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataEC50:  1.39E+3nMpH: 7.2 T: 2°CAssay Description:Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50526790(CHEMBL4555799)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583916(CHEMBL4786320)
Affinity DataKd:  0.150nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583917(CHEMBL4800180)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583918(CHEMBL4791134)
Affinity DataKd:  0.0700nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583919(CHEMBL5083688)
Affinity DataKd:  0.0900nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583920(CHEMBL4786843)
Affinity DataKd:  0.340nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583921(CHEMBL4779443)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583922(CHEMBL4786555)
Affinity DataKd:  0.210nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583923(CHEMBL4786592)
Affinity DataKd:  0.0800nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583924(CHEMBL4790490)
Affinity DataKd:  0.100nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583925(CHEMBL4782954)
Affinity DataKd:  0.0800nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583926(CHEMBL4798916)
Affinity DataKd:  0.150nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583927(CHEMBL5088381)
Affinity DataKd:  0.0300nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583928(CHEMBL5080711)
Affinity DataKd:  0.0600nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Syros Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50583929(Sy 5609 | Sy-5609 | SY5609 | SY-5609)
Affinity DataKd:  0.0700nMAssay Description:Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585812(CHEMBL5091943)
Affinity DataEC50:  64nMAssay Description:Activation of recombinant human full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 5 mM glucose by plat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585813(CHEMBL5072532)
Affinity DataEC50:  53nMAssay Description:Activation of recombinant human full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 5 mM glucose by plat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585812(CHEMBL5091943)
Affinity DataEC50:  38nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585814(CHEMBL5071861)
Affinity DataEC50:  75nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585815(CHEMBL5083525)
Affinity DataEC50:  49nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585816(CHEMBL5086985)
Affinity DataEC50:  164nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585817(CHEMBL5075882)
Affinity DataEC50:  169nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585818(CHEMBL5080889)
Affinity DataEC50:  679nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585819(CHEMBL5088988)
Affinity DataEC50:  79nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585820(CHEMBL5093208)
Affinity DataEC50:  98nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585821(CHEMBL5093978)
Affinity DataEC50:  48nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585822(CHEMBL5083369)
Affinity DataEC50:  87nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585823(CHEMBL5081517)
Affinity DataEC50:  76nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585824(CHEMBL5084870)
Affinity DataEC50:  24nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585825(CHEMBL5086686)
Affinity DataEC50:  530nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585826(CHEMBL5085491)
Affinity DataEC50:  234nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585827(CHEMBL5088522)
Affinity DataEC50:  159nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585828(CHEMBL5076695)
Affinity DataEC50:  28nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585829(CHEMBL5092846)
Affinity DataEC50:  32nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585830(CHEMBL5072442)
Affinity DataEC50:  67nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585831(CHEMBL5076377)
Affinity DataEC50:  25nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585832(CHEMBL5087489)
Affinity DataEC50:  188nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585813(CHEMBL5072532)
Affinity DataEC50:  29nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585833(CHEMBL5094606)
Affinity DataEC50:  61nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHexokinase-4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585834(CHEMBL5077438)
Affinity DataEC50:  1.24E+3nMAssay Description:Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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