Compile Data Set for Download or QSAR
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Found 97 of ic50 for monomerid = 19441
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.180nMAssay Description:Antagonist activity at FLAG-tagged ERalpha (unknown origin) expressed in HEK293 cells assessed as reduction in E2-induced ER-alpha-mediated transcrip...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibition of estrogen-stimulated MCF-7 cell proliferationMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.200nMAssay Description:Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-est...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist effect in breast tissue was assayed by inhibition of estrogen stimulated MCF-7 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetEstrogen receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferationMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at human wild type ERalpha expressed in HEK293T cells co-expressing ERE assessed as inhibition of estradiol-induced transactivati...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of 17-beta-estradiol (10e-11 M) mediated MCF-7 cell proliferationMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.460nMAssay Description:Antagonist activity at human ERalpha expressed in african green monkey CV1 cells assessed as inhibition of estrogen like activity after 24 hrs by luc...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.470nMAssay Description:Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of transcriptional activation induced by 1 nM 17-beta estradiol in T47D cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.700nMAssay Description:Binding affinity for Rat Estrogen receptor-alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.720nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.720nMAssay Description:Antagonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.740nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.890nMAssay Description:Inhibitino of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor betaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity for Human Estrogen receptor-alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity towards human recombinant Estrogen receptor alpha was determinedMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity to ERalphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity against human estrogen receptor alpha in competitive binding assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity towards human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of binding to recombinant human ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of bindign to recombinant human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human estrogen receptor 2 using tritiated estradiol incubated for 3 hrMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(RAT)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of estradiol binding to estrogen receptorMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]17-beta-estradiol from human Estrogen receptor alphaMore data for this Ligand-Target Pair
TargetAldehyde oxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human aldehyde oxidaseMore data for this Ligand-Target Pair
TargetAldehyde oxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human aldehyde oxidaseMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  3.40nMAssay Description:Binding affinity foor Rat Estrogen receptor-betaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibition of human ERalpha/ERbeta co-expressed in HEK 293 cells; 4/60More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetAldehyde oxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human AOX using phthalazine as substrate preincubated for 30 mins followed by substrate addition by HPLC-MS analysisMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  5.90nMAssay Description:Antagonist activity at ER-alpha in human MCF-7:WS8 cells transfected with an estrogen response element assessed as suppression of estrogen-induced re...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  6.90nMAssay Description:Antagonist activity at human wild type ERbeta expressed in HEK293T cells co-expressing ERE assessed as inhibition of estradiol-induced transactivatio...More data for this Ligand-Target Pair
TargetEstrogen receptor(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  7nMAssay Description:Binding to Estrogen receptor- alpha (ER alpha) receptorMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  7nMAssay Description:In vitro binding affinity for estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  7.70nMAssay Description:Displacement of [3H]17-beta-estradiol from Estrogen receptor of rabbit uterine tissueMore data for this Ligand-Target Pair
TargetAldehyde oxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Homo sapiens (human) aldehyde oxidaseMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  8.20nMAssay Description:Binding affinity to ERbetaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  12nMAssay Description:Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  12nMAssay Description:Inhibition of binding to recombinant human ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor betaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  12nMAssay Description:Binding affinity towards human recombinant Estrogen receptor beta was determinedMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  12nMAssay Description:Inhibition of binding to recombinant human estrogen receptor betaMore data for this Ligand-Target Pair
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