Found 331 of ic50 for monomerid = 50380399 TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human HDAC6 pre-incubated for 5 mins before substrate addition and measured after 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 2nMT: 2°CAssay Description:Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human HDAC6 using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of N-terminal GST tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using RHKKAc as substrate in pres...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells preincubated with enzyme followed...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductaseMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human full length recombinant HDAC6 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 4nMpH: 8.0Assay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of HDAC6 in mouse N2A cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:The effectiveness, or potency, of a present HDACI with respect to inhibiting the activity of an HDAC is measured by an IC50 value. The quantitative I...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 9.40nMAssay Description:Inhibition of HDAC6 (unknown origin) measured by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate 3 pre-incubated for 30 mins followed by HDAC developer addition and measured a...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of choline acetyltransferase (CAT) enzymeMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against acetylcholinetransferase (AChE) enzymeMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
European Molecular Biology Laboratory
Curated by ChEMBL
European Molecular Biology Laboratory
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 13.7nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in Sf9 cells using RHKK(Ac) as substrate after 90 mins by fluorimet...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human HDAC6 using fluorogenic-(RHKKAc) as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using Z-Lys(Ac)-AMC as fluorogenic sub...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic peptide RHKKAc-AMC as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-Lys(Ac)-AMC) fluorogenic substrate incubated for 90 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human KDAC6 using acetylated p53 (379 to 382 residues) as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombiant human HDAC6 using fluorogenic HDAC substrate 3 measured after 30 mins by fluorescence microplate reader assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc peptide as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKKAc fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMpH: 8.0 T: 2°CAssay Description:Following transfection of HEK293 cells with pBJ5-HDAC1 wild type or mutant plasmids, [Weerasinghe et al., J. Med. Chem. 51:5542-5551; Wambua et al., ...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant N-GST-tagged HDAC6 (unknown origin) assessed as reduction in deacetylation of Ac-Arg-Gly-Lys(Ac)-AMC substrate by fluoresce...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc peptide as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAc peptide as substrate incubated for 5 to mins prior to substrate addition measured after 2 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant full-length HDAC6 expressed in baculovirus infected Sf9 cells using Boc-Lys(acetyl)-AMC as substrate after 30 mins by...More data for this Ligand-Target Pair
