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Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 0.460nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Amri

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 0.520nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
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Cyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: >0.600nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 0.700nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 0.700nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells using histone H1 as substrate incubated for 10 mins in prese...More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
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Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 4.60nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 18nMAssay Description:Inhibition of His-tagged CDK2/cyclin E1 (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of ATP and [gamma33-P]ATP b...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 43nMAssay Description:Inhibition of CDK2/Cyclin A2 (unknown origin) after 10 mins by ADP-Glo reagent based assayMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 72nMAssay Description:Inhibition of recombinant human CDK2/cyclin A after 30 mins in presence of [gamma-33P] by scintillation counting methodMore data for this Ligand-Target Pair

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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Egyptian Russian University

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 82nMAssay Description:Inhibition of CDK1/cyclinB (unknown origin)More data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))TBA

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 82nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 90nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Cyclin-C(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: >100nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin)More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2/cyclinE assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair

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PDB Reactome pathway
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells using histone H1 as substrate in presence of [gamma3...More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of human CDK2/cyclin E (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addi...More data for this Ligand-Target Pair

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PDB Reactome pathway
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Amri

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Cyclin-dependent kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 100nMAssay Description:Binding affinity to CDK2More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 110nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK2/CyclinA2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate incuba...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 140nMAssay Description:Inhibition of CDK2-cyclinA in the presence of 20uM ATPMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 158nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in sf9 cells using histone H1 as substrate in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMAssay Description:Compound was tested for its inhibitory activity against cyclin-dependent kinase 5More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMAssay Description:Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation countingMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMAssay Description:Inhibition of CDK5/p25 (unknown origin)More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Cnrs

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 160nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair

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Details PubMed MMDB
PDB

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 193nMAssay Description:Inhibition of wild-type human N-terminal GST-tagged CDK2/cycA2 expressed in Sf21 insect cells using FAM-labelled substrate preincubated for 10 mins f...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Cnrs

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of recombinant human CDK5/p25 after 30 mins in presence of [gamma-33P] by scintillation counting methodMore data for this Ligand-Target Pair

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Cyclin-dependent kinase 1(Homo sapiens (Human))TBA

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair

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Details Article PubMed

Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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PDB Reactome pathway KEGG
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Cyclin-dependent kinase 1(Homo sapiens (Human))TBA

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of Cdc2 (unknown origin)More data for this Ligand-Target Pair

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Details Article PubMed

Cyclin-dependent kinase 5(Bos taurus)
Hefei University Of Technology

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of bovine brain CDK5 using histone H1 as substrate incubated for 15 mins in presence of [gamma-32P]ATP by radiometric scintillation assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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PDB MMDB NCI pathway Reactome pathway KEGG
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Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of human recombinant CDK5/P25 using myelin basic protein substrateMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of cyclin-dependent kinase 5/p25; range 0.1-0.2More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Cyclin-dependent kinase 5(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 200nMAssay Description:Inhibition of recombinant human CDK5/p25 after 30 mins by scintillation countingMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
The People'S Hospital Of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 220nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palack£

Curated by ChEMBL

BDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)

IC50: 220nMAssay Description:Inhibition of human recombinant CDK2/cyclin EMore data for this Ligand-Target Pair

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