Compile Data Set for Download or QSAR
Found 221 of ec50 for UniProtKB: P05067
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM4078(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)
Affinity DataEC50:  1.70nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by inverted fluorescence microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50085536(3,4,5-Trihydroxybenzoate, X | 3,4,5-trihydroxybenz...)
Affinity DataEC50:  1.70nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50595332(CHEMBL5179584)
Affinity DataEC50:  1.90nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by inverted fluorescence microscopic analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50242279(6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-21-(3,...)
Affinity DataEC50:  3.20nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by inverted fluorescence microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50085536(3,4,5-Trihydroxybenzoate, X | 3,4,5-trihydroxybenz...)
Affinity DataEC50:  3.20nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by inverted fluorescence microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446555(7-(2-Chloro-4-fluorophenyl)-N2-(3-fluoro-4-(4-meth...)
Affinity DataEC50:  4nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM50465355(CHEMBL4285214 | US10669276, Example 1)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446501(7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446556((S)- or (R)N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446553(7-(2,3-Difluorophenyl)-N2-(3-fluoro-4-(4-methyl-1H...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446554(7-(2,3-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446518(7-(3,4-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...)
Affinity DataEC50:  5nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446536(7-(2,4-Difluorophenyl)-N2-(5-fluoro-6-(4-methyl-1H...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446539(2-((7-(4-Fluorophenyl)-2-((5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446543(7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446548(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446549(7-(4-Fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM4078(6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...)
Affinity DataEC50:  6nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446550(7-(4-Fluorophenyl)-N2-(5-methoxy-6-(4-methyl-1H-im...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM455363(7-(2,3-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50242278(CHEMBL506069 | Geraniin | geraniiin)
Affinity DataEC50:  6.70nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by inverted fluorescence microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50595332(CHEMBL5179584)
Affinity DataEC50:  6.70nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM50465354(CHEMBL4293045 | US10669276, Example 4)
Affinity DataEC50:  7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform APP695 of Amyloid-beta precursor protein [K595N,M596L](Homo sapiens (Human))
Hoffmann-La Roche Inc.

US Patent
LigandPNGBDBM476529(N-((8 endo)-3-(3-methylisothiazol-5-yl)-3-azabicyc...)
Affinity DataEC50:  7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446557((R) or (S)N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1...)
Affinity DataEC50:  7nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446485(N2-(3-(Difluoromethoxy)-4-(3-methyl-1H-1,2,4-triaz...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446525(7-(3,4-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446529(7-(2,4-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446530(7-(2,4-Difluorophenyl)-N2-(5-methoxy-6-(4-methyl-1...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446533(N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM50465357(CHEMBL4283902 | US10669276, Example 25)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM50465360(CHEMBL4294948 | US10669276, Example 28)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446544(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446547(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446552(7-(2,3-Difluorophenyl)-N2-(5-fluoro-6-(4-methyl-1H...)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform APP695 of Amyloid-beta precursor protein [K595N,M596L](Homo sapiens (Human))
Hoffmann-La Roche Inc.

US Patent
LigandPNGBDBM50502721(CHEMBL4435639 | US11440915, Example 9)
Affinity DataEC50:  8nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50242279(6,7,8,11,12,13,22,23-octahydroxy-3,16-dioxo-21-(3,...)
Affinity DataEC50:  8.90nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446491(N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446551(7-(2,3-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM455353(7-(2,4-Difluorophenyl)-N2-((1R,5S,8s)-3-(6-methoxy...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM455355(2-((7-(4-Fluorophenyl)-2-(((1R,5S,8s)-3-(6-methoxy...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM455358(7-(2,3-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform APP695 of Amyloid-beta precursor protein [K595N,M596L](Homo sapiens (Human))
Hoffmann-La Roche Inc.

US Patent
LigandPNGBDBM476532(N-((8 endo)-3-(2-chloropyridin-4-yl)-3-azabicyclo[...)
Affinity DataEC50:  9.20nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446524(N2-(6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446542(7-(4-Fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50242278(CHEMBL506069 | Geraniin | geraniiin)
Affinity DataEC50:  10nMAssay Description:Inhibition of amyloid beta 1 to 42 aggregation (unknown origin) incubated for 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIsoform APP695 of Amyloid-beta precursor protein [K595N,M596L](Homo sapiens (Human))
Hoffmann-La Roche Inc.

US Patent
LigandPNGBDBM571405((9R)-N-[3-(4-methylimidazol-1-yl)-1-bicyclo[1.1.1]...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM455364(7-(2,3-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein [672-713](Homo sapiens (Human))
HOFFMANN-LA ROCHE INC.

US Patent
LigandPNGBDBM446540(2-((2-((6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyr...)
Affinity DataEC50:  11nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Muroran Institute of Technology

Curated by ChEMBL
LigandPNGBDBM455341(N2-((1R,5S,8s)-3-(6-Chloropyridazin-4-yl)-3-azabic...)
Affinity DataEC50:  11nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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