Affinity DataEC50: 4.70nMAssay Description:Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by...More data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by...More data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 29nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Inhibition of HDAC in human cell lysates using fluoro-substrate peptide/fluoro-deacetylated peptide as substrate incubated for 20 mins measured at 1 ...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)
Curated by ChEMBL
S£O Paulo State University (Unesp)
Curated by ChEMBL
Affinity DataEC50: 41nMAssay Description:Inhibition of recombinant human HDAC1 expressed in baculovirus expression system using KI-104 as substrate incubated for 3 hrs by by fluorescence-bas...More data for this Ligand-Target Pair
Affinity DataEC50: 42nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 47nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 55nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 5% NH...More data for this Ligand-Target Pair
Affinity DataEC50: 59nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 60nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 77nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% ...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 82nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 88nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 90nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 91nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 95nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 97nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 5% NH...More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 105nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% ...More data for this Ligand-Target Pair
Affinity DataEC50: 107nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)
Curated by ChEMBL
S£O Paulo State University (Unesp)
Curated by ChEMBL
Affinity DataEC50: 110nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H4 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 161nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% ...More data for this Ligand-Target Pair
Affinity DataEC50: 165nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 5% NH...More data for this Ligand-Target Pair
Affinity DataEC50: 166nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% ...More data for this Ligand-Target Pair
Affinity DataEC50: 170nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 175nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 5% NH...More data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:Inhibition of class 1 HDAC in human Jurkat model of HIV latency assessed as reactivation of HIV latency incubated for 20 hrs in presence of 5% NHS by...More data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Inhibition of HDAC in human cell lysates using fluoro-substrate peptide/fluoro-deacetylated peptide as substrate incubated for 20 mins measured at 1 ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 190nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 193nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
S£O Paulo State University (Unesp)
Curated by ChEMBL
S£O Paulo State University (Unesp)
Curated by ChEMBL
Affinity DataEC50: 200nMAssay Description:Inhibition of HDAC1 in human MM96L cells assessed as activation of histone H4 acetylation at Lys5, Lys8, Lys12 and Lys16 residues by Western blot ana...More data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Inhibition of HDAC activity in human NB4 cells assessed as acetylation of histone H3 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 233nMAssay Description:Inhibition of Class 1 HDAC in VSV-G-pseudotyped HIV infected human 2C4 cell Jurkat model assessed as reactivation of HIV latency in presence of 0.1% ...More data for this Ligand-Target Pair
Affinity DataEC50: 240nMAssay Description:Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylationMore data for this Ligand-Target Pair
