Compile Data Set for Download or QSAR
Report error Found 120 of ec50 for UniProtKB: P42338
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50420309(CHEMBL2089120)
Affinity DataEC50:  3nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501408(CHEMBL4081433)
Affinity DataEC50:  3.70nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501405(CHEMBL4074361)
Affinity DataEC50:  4.20nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)
Affinity DataEC50:  5nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM315499(US10172858, Table 1.22)
Affinity DataEC50:  5.30nMAssay Description:Inhibition of PI3K beta (unknown origin) by PIP3 production detection based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  5.40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  5.70nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50420311(CHEMBL2089114)
Affinity DataEC50:  6nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420310(CHEMBL2089116)
Affinity DataEC50:  6nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)
Affinity DataEC50:  6nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataEC50:  6.30nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  7.30nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP cells assessed as decrease in AKT1 phosphorylation at Ser473 after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50501410(CHEMBL4101102)
Affinity DataEC50:  7.60nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)
Affinity DataEC50:  9nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50420312(CHEMBL2089109)
Affinity DataEC50:  9nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >10nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >10nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)
Affinity DataEC50:  12nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)
Affinity DataEC50:  12nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataEC50:  15nMAssay Description:Inhibition of PI3K-beta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50501415(CHEMBL4085918)
Affinity DataEC50:  15nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)
Affinity DataEC50:  15nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)
Affinity DataEC50:  15nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP C4-2 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataEC50:  15nMAssay Description:Inhibition of PI3Kbeta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50420313(CHEMBL2089108)
Affinity DataEC50:  16nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataEC50:  16nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50420314(CHEMBL2089107)
Affinity DataEC50:  19nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50501398(CHEMBL4082978)
Affinity DataEC50:  20nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataEC50:  21nMAssay Description:Inhibition of PI3Kbeta in human 786-0 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Affinity DataEC50:  23nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataEC50:  24nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)
Affinity DataEC50:  24nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP C4-2 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50489455(CHEMBL2322337)
Affinity DataEC50:  25nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Affinity DataEC50:  28nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)
Affinity DataEC50:  31nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCAP cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50489445(CHEMBL2322331)
Affinity DataEC50:  32nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Affinity DataEC50:  40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50501416(CHEMBL4102306)
Affinity DataEC50:  42nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM198031(US9221795, 27)
Affinity DataEC50:  42nMAssay Description:Inhibition of PI3K p110beta in human PC-3 cells assessed as reduction in AKT phosphorylation at S473 residue measured after 2 hrs by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)
Affinity DataEC50:  42nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP C4-2 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataEC50:  44nMAssay Description:Inhibition of PI3K-beta (unknown origin) after 40 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50315213(TCMDC-137004 | 2-(difluoromethyl)-1-(4,6-dimorphol...)
Affinity DataEC50:  44nMAssay Description:Inhibition of PI3Kbeta (unknown origin) after 40 mins by kinase-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50501413(CHEMBL4079545)
Affinity DataEC50:  45nMAssay Description:Inhibition of PI3K p110beta in PTEN-deficient human PC3 cells assessed as decrease in AKT phosphorylation at ser473 after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandPNGBDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)
Affinity DataEC50:  53nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCAP cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM185147(BGT-226 | (Z)-but-2-enedioic acid;8-(6-methoxypyri...)
Affinity DataEC50:  56nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM185147(BGT-226 | (Z)-but-2-enedioic acid;8-(6-methoxypyri...)
Affinity DataEC50:  63nMAssay Description:Inhibition of PI3K beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM185147(BGT-226 | (Z)-but-2-enedioic acid;8-(6-methoxypyri...)
Affinity DataEC50:  63nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50489446(CHEMBL2322336)
Affinity DataEC50:  63nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
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