Affinity DataEC50: 7.10nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET cloned in rat brain synaptosome by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Agonist activity at NETMore data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at NETMore data for this Ligand-Target Pair
Affinity DataEC50: 49nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 65nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 83nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 97nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 239nMAssay Description:Agonist activity at human cloned NET expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 251nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 254nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 310nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataEC50: 339nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 358nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 830nM EC50: 385nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataKi: 2.44E+3nM EC50: 481nMAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
Affinity DataEC50: 490nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataKi: 2.27E+3nM EC50: 582nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataKi: 1.27E+3nM EC50: 620nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 627nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataKi: 2.51E+3nM EC50: 650nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 670nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nM EC50: 690nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 740nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataKi: 1.84E+3nM EC50: 750nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 827nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataKi: 1.12E+3nM EC50: 835nMAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
Affinity DataEC50: 900nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nM EC50: 912nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataKi: 1.75E+3nM EC50: 957nMAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
Affinity DataKi: 3.29E+3nM EC50: 960nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 980nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataKi: 990nM EC50: 2.04E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Binding affinity to human NET expressed in HEK293 cells assessed as induction of [3H]MPP+ release by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.56E+3nM EC50: 1.02E+3nMAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
Affinity DataKi: 2.87E+3nM EC50: 1.17E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 1.18E+3nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataEC50: 1.38E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.39E+3nM EC50: >6.90E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 1.39E+3nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 1.52E+3nMAssay Description:Inhibition of NET (unknown origin) expressed in HEK293 cells assessed as reduction in norepinephrine reuptakeMore data for this Ligand-Target Pair
Affinity DataEC50: 1.52E+3nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair
Affinity DataKi: 1.97E+3nM EC50: 1.55E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataKi: 1.63E+3nM EC50: 4.87E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
Affinity DataEC50: 1.76E+3nMAssay Description:Enhancing of [125I]RTI-55 binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand additi...More data for this Ligand-Target Pair















































