Compile Data Set for Download or QSAR
maximum 50k data
Found 52 of ic50 for UniProtKB: P34975
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM21130(N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...)
Affinity DataIC50:  0.630nMAssay Description:Inhibitory activity against forskolin-stimulated cAMP production in chinese hamster ovary cells expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.640nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa-type opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.680nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50359546(CHEMBL1927270)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of Wistar rat brain membrane KOPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001852(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-1-{2-[(3...)
Affinity DataIC50:  10nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50594837(CHEMBL5200728)
Affinity DataIC50:  32nMAssay Description:Inhibition of Wistar rat brain membrane KOPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304084(3-(2-(3-tert-Butylphenyl)-5-((dimethylamino)methyl...)
Affinity DataIC50:  46nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50036787(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(R)-1...)
Affinity DataIC50:  221nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001849(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-1-[2-(3-...)
Affinity DataIC50:  280nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50453625(CHEMBL2110229)
Affinity DataIC50:  316nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001848(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[1-met...)
Affinity DataIC50:  330nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304082(3-(5-(3-tert-Butylphenyl)-3-((dimethylamino)methyl...)
Affinity DataIC50:  341nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304083(3-(3-((Dimethylamino)methyl)-5-(2,4-dimethylphenyl...)
Affinity DataIC50:  351nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001850((S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[(...)
Affinity DataIC50:  380nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50007329((R)-2-[(R)-2-(2-{2-[(R)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  400nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304076(3-(2-(4-tert-Butylphenyl)-5-((dimethylamino)methyl...)
Affinity DataIC50:  760nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50036802((S)-2-Amino-N-cyclopropylmethyl-3-(4-hydroxy-2,6-d...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50067811(7-Ethyl-9-phenyl-6,7,8,9-tetrahydro-5H-10-thia-7-a...)
Affinity DataIC50:  1.30E+3nMAssay Description:relative affinity against Opioid receptor kappa 1 in insular Ctx using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001846(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[1-met...)
Affinity DataIC50:  1.30E+3nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50036790(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-2-methyl...)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50453616(CHEMBL2110337)
Affinity DataIC50:  2.52E+3nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataIC50:  3.60E+3nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304075(3-(5-(4-tert-butylphenyl)-3-((dimethylamino)methyl...)
Affinity DataIC50:  3.85E+3nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50067814(17-ethyl-(1R,17S)-3,13-diazapentacyclo[13.3.1.02,1...)
Affinity DataIC50:  4.24E+3nMAssay Description:relative affinity against Opioid receptor kappa 1 in insular Ctx using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001851(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-(1-met...)
Affinity DataIC50:  5.40E+3nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001845(2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-N-[2-hyd...)
Affinity DataIC50:  5.90E+3nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450653(CHEMBL2115493)
Affinity DataIC50:  6.31E+3nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001853(2-Amino-N-(2-fluoro-1-methyl-6-phenyl-hex-2-enyl)-...)
Affinity DataIC50:  8.00E+3nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50001847(2-Amino-N-[2-tert-butoxy-1-(3-phenyl-propoxymethyl...)
Affinity DataIC50:  9.30E+3nMAssay Description:Binding ability towards opioid receptor kappa expressed in homogenates of rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50071201((R)-2-[(R)-2-(2-{(R)-2-[(R)-2-Amino-3-(4-hydroxy-p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50071202((R)-2-[(R)-2-(2-{(S)-2-[(R)-2-Amino-3-(4-hydroxy-p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50071199((R)-2-[(R)-2-(2-{2-[(R)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50323040(1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylamin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]U69593 from rat recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304081((5-(3-tert-Butylphenyl)-1-(3-methoxyphenyl)-1H-1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304080((5-(4-tert-Butylphenyl)-1-(3-methoxyphenyl)-1H-1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304079((5-(2,4-Dimethylphenyl)-1-(3-methoxyphenyl)-1H-1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304078((1-(3-tert-Butylphenyl)-5-(3-methoxyphenyl)-1H-1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50304077((1-(4-tert-Butylphenyl)-5-(3-methoxyphenyl)-1H-1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]bremazocine from rat kappa opioid receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450656(CHEMBL2114469)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450655(CHEMBL2114470)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50450654(CHEMBL2115492)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against rat kappa-opioid receptor expressed in CHO cells was determined by competitive inhibition of 2 nM [3H]-U 69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50036793(2-Amino-3-[4-(4-fluoro-benzyloxy)-2,6-dimethyl-phe...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50067816(9-(3-Bromo-phenyl)-7-ethyl-6,7,8,9-tetrahydro-5H-1...)
Affinity DataIC50:  1.25E+4nMAssay Description:relative affinity against Opioid receptor kappa 1 in insular Ctx using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50067810(9-(3,4-Dichloro-phenyl)-7-ethyl-6,7,8,9-tetrahydro...)
Affinity DataIC50:  1.59E+4nMAssay Description:relative affinity against Opioid receptor kappa 1 in insular Ctx using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50067815(7-Ethyl-9-(3-nitro-phenyl)-6,7,8,9-tetrahydro-5H-1...)
Affinity DataIC50:  1.62E+4nMAssay Description:relative affinity against Opioid receptor kappa 1 in insular Ctx using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50453628(CHEMBL2110227)
Affinity DataIC50:  1.75E+4nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50453629(CHEMBL170594)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibitory concentration of the compound was evaluated against kappa opioid receptor by displacement of tritiated U-69593 from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50067809(3-Methyl-5-phenyl-1,2,3,4,5,6-hexahydro-azepino[4,...)
Affinity DataIC50:  2.12E+4nMAssay Description:relative affinity against Opioid receptor kappa 1 in insular Ctx using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50206577(10-methoxyibogamine | CHEMBL222287 | IBOGAINE)
Affinity DataIC50:  2.50E+4nMAssay Description:relative affinity against Opioid receptor kappa 1 in insular Ctx using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50544378(CHEMBL4639111)
Affinity DataIC50:  2.51E+4nMAssay Description:Antagonist activity at rat KOR expressed in CHOK1 cells assessed as inhibition of U50488-induced increase in cAMP accumulation measured after 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 52 total ) | Next | Last >>
Jump to: