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TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50386178(ONO-1714 | CHEMBL1800346)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50386178(ONO-1714 | CHEMBL1800346)
Affinity DataKi:  1.86nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50138191(ONO-1714 | (1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-b...)
Affinity DataKi:  2nMAssay Description:Inhibition of human iNOS overexpressed in baculovirus infected Sf21 cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataKi:  2.20nMAssay Description:Binding against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50271827(S-ISOPROPYL-ISOTHIOUREA | 2-Isopropyl-isothiourea ...)
Affinity DataKi:  9nMAssay Description:Inhibition of iNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50626248(CHEMBL106871)
Affinity DataKi:  17nMAssay Description:Inhibition of human iNOS assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065823(N-(3-Aminomethyl-phenyl)-2-methylsulfanyl-acetamid...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50240717(2-{2-[3-(2-Carbamimidoylsulfanyl-ethyl)-phenyl]-et...)
Affinity DataKi:  47nMAssay Description:Inhibition of iNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against L-arginine binding to Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065843(CHEMBL555715 | CHEMBL553081 | N-(3-Aminomethyl-phe...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065805(N-(3-Aminomethyl-benzyl)-acetamidine | CHEMBL54478...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065807(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  160nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50095181(N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | C...)
Affinity DataKi:  160nMAssay Description:Inhibition of human iNOS assessed as reduction of L-[14C]arginine to L-[14C]-citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | S-ethyl-iso-thiourea | S-ETH...)
Affinity DataKi:  190nMAssay Description:Inhibition of iNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50271829(2-Propyl-isothiourea | CHEMBL483092)
Affinity DataKi:  240nMAssay Description:Inhibition of iNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  273nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50072297(5-Acetimidoylamino-2-(S)-amino-pentanoic acid | CH...)
Affinity DataKi:  340nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065813(N-(3-Aminomethyl-phenyl)-2-fluoro-acetamidine | CH...)
Affinity DataKi:  480nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  581nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50289681(2-Amino-3-[2-(N'-methyl-guanidino)-phenyl]-propion...)
Affinity DataKi:  600nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50592473(CHEMBL5191295)
Affinity DataKi:  669nMAssay Description:Inhibition of human iNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataKi:  670nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341684(NOS Inhibitor, 3h | CHEMBL1766633 | 6,6'-(2,2'-(1,...)
Affinity DataKi:  682nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5 microplate reader. IC50 values for each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275051(US9878996, Compound 7)
Affinity DataKi:  770nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50230993(CHEMBL256147 | 2-Amino-5-(N'-methyl-guanidino)-pen...)
Affinity DataKi:  860nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50230993(CHEMBL256147 | 2-Amino-5-(N'-methyl-guanidino)-pen...)
Affinity DataKi:  860nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058459(CHEMBL545673 | CHEMBL451666 | 2-Ethyl-1-phenyl-iso...)
Affinity DataKi:  870nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50626253(CHEMBL451666)
Affinity DataKi:  870nMAssay Description:Inhibition of human iNOS assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275050(US9878996, Compound 6)
Affinity DataKi:  1.10E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50526363(CHEMBL4440481)
Affinity DataKi:  1.31E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058448(CHEMBL543085 | CHEMBL502814 | 2-Ethyl-1-(2-methoxy...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341682(NOS Inhibitor, 3j | 6,6'-(pyridine-3,5-diyldiethan...)
Affinity DataKi:  1.45E+3nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341682(NOS Inhibitor, 3j | 6,6'-(pyridine-3,5-diyldiethan...)
Affinity DataKi:  1.45E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5 microplate reader. IC50 values for each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065842(N-(4-{[3-(1-Imino-ethyl)-benzylamino]-methyl}-phen...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50526359(CHEMBL4450896)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50620568(CHEMBL5436523)
Affinity DataKi:  1.72E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using human oxyhemoglobin by hemoglobin (Hb) NO capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50526373(CHEMBL4590333)
Affinity DataKi:  1.78E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275056(US9878996, Compound 29)
Affinity DataKi:  1.80E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50441007(CHEMBL2430149 | US9732037, Compound 19)
Affinity DataKi:  1.86E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50014713(CHEMBL3262022 | US9951014, Name 6 | US10759791, Co...)
Affinity DataKi:  1.89E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5 microplate reader. IC50 values for each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50289677(3-(2-Acetimidoylamino-phenyl)-2-amino-propionic ac...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058443(CHEMBL543098 | CHEMBL476196 | 2-Ethyl-1-p-tolyl-is...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275053(US9878996, Compound 26)
Affinity DataKi:  1.90E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50446249(CHEMBL3109189 | US9732037, Compound 8)
Affinity DataKi:  1.90E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341681(6-(2-{5-[2-(2-amino-6-methylpyridin-4-yl)ethyl]pyr...)
Affinity DataKi:  1.91E+3nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065841(N-[4-(Acetimidoylamino-methyl)-phenyl]-acetamidine...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065833(N-(4-Aminomethyl-phenyl)-acetamidine | CHEMBL54243...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275052(US9878996, Compound 25)
Affinity DataKi:  2.00E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM344408(US9783500, Compound 4 | US9783500, Compound 10)
Affinity DataKi:  2.08E+3nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  2.15E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5 microplate reader. IC50 values for each comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

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