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TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50626248(CHEMBL106871)
Affinity DataIC50: 1nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091817(CHEMBL302657 | 4-Methyl-6-propylpyridin-2-amine, 7...)
Affinity DataIC50: 10nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50363262(CHEMBL1944717)
Affinity DataIC50: 12nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111496(US8618286, 22)
Affinity DataIC50: 14nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2Z)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50352593(CHEMBL1825174)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091817(CHEMBL302657 | 4-Methyl-6-propylpyridin-2-amine, 7...)
Affinity DataIC50: 23nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111497(US8618286, 23)
Affinity DataIC50: 28nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50206074((+/-)-N-{2-[2-(1-methyl-pyrrolidin-2-yl)-ethylamin...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human neuronal NOS activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50164777((4R,7R)-4-Methyl-octahydro-[1]pyrindin-(2E)-yliden...)
Affinity DataIC50: 31nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50164777((4R,7R)-4-Methyl-octahydro-[1]pyrindin-(2E)-yliden...)
Affinity DataIC50: 31nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111490(US8618286, 16)
Affinity DataIC50: 34nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50122307(CHEMBL293212 | N-{4-[2-(3-Chloro-benzylamino)-ethy...)
Affinity DataIC50: 35nMAssay Description:Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50430743(CHEMBL2333953)
Affinity DataIC50: 35nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50164784((4S,7S)-4-Methyl-octahydro-[1]pyrindin-(2E)-yliden...)
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091800(4-METHYLPYRIDIN-2-AMINE, 6 | 4-METHYLPYRIDIN-2-AMI...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50138977(N-(3-Aminomethyl-phenyl)-acetamidine | N-(3-Aminom...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50401280(CHEMBL3216124)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of [3H]-larginine to [3H]-L-citrulline preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50128920(CHEMBL545441 | CHEMBL162416 | (3R,3aS)-7-[3-(3-Chl...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50128920(CHEMBL545441 | CHEMBL162416 | (3R,3aS)-7-[3-(3-Chl...)
Affinity DataIC50: 42nMAssay Description:Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50363270(CHEMBL1944884)
Affinity DataIC50: 46nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50128916((3aR,9bS)-7-[2-(3-Chloro-benzylamino)-ethyl]-2,3,3...)
Affinity DataIC50: 48nMAssay Description:Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM36402(CID24894154 | (3R)-3-Propyl-2,3-dihydrothieno[2,3-...)
Affinity DataIC50: 50nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111498(US8618286, 24)
Affinity DataIC50: 50nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50141086(6-[7-(2-Dimethylamino-ethoxy)-indan-4-yl]-pyridin-...)
Affinity DataIC50: 50.6nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50164782((4R,4aR,5R)-4-Methyl-octahydro-quinolin-(2E)-ylide...)
Affinity DataIC50: 53nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50150885(6-(4-Dimethylaminomethyl-5-ethyl-2-methoxy-phenyl)...)
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50150887(6-[4-(2-Dimethylamino-ethoxy)-5-ethyl-2-methoxy-ph...)
Affinity DataIC50: 58nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111482(US8618286, 8)
Affinity DataIC50: 60nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50138983(2-(S)-Amino-5-(2-methyl-isothioureido)-pentanoic a...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration against human neuronal nitric oxide synthase expressed in Sf-9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50352592(CHEMBL1825173)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50363266(CHEMBL1944721)
Affinity DataIC50: 60nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50124519(5,8-Difluoro-2-furan-2-yl-1,2-dihydro-quinazolin-4...)
Affinity DataIC50: 60nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50363277(CHEMBL1945066)
Affinity DataIC50: 62nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50363269(CHEMBL1944724)
Affinity DataIC50: 64nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50363263(CHEMBL1944718)
Affinity DataIC50: 69nMAssay Description:Inhibition of human nNOS expressed in HEK293 cells assessed as NO production by 2,3-diaminonapthalene-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50352591(CHEMBL1825172)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50365335(CHEMBL1955937)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]L-arginine to [3H]L-citrulline ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50141082(6-[4-(2-Dimethylamino-ethoxy)-5,6,7,8-tetrahydro-n...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50141081(6-[4-(1-Methyl-pyrrolidin-3-yloxy)-naphthalen-1-yl...)
Affinity DataIC50: 70.3nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50141082(6-[4-(2-Dimethylamino-ethoxy)-5,6,7,8-tetrahydro-n...)
Affinity DataIC50: 70.9nMAssay Description:In vitro inhibition of human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50091800(4-METHYLPYRIDIN-2-AMINE, 6 | 4-METHYLPYRIDIN-2-AMI...)
Affinity DataIC50: 75nMAssay Description:Inhibitory activity against neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50150884(6-[4-(3-Dimethylamino-propyl)-5-ethyl-2-methoxy-ph...)
Affinity DataIC50: 75nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50150890(6-[4-(2-Dimethylamino-ethyl)-5-ethyl-2-methoxy-phe...)
Affinity DataIC50: 75nMAssay Description:Inhibitory activity against neuronal nitric oxide synthase in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM36401(CID24894153 | (2S)-2-Methyl-2,3-dihydrothieno[2,3-...)
Affinity DataIC50: 80nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2011
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111484(US8618286, 10)
Affinity DataIC50: 80nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM111502(US8618286, 28)
Affinity DataIC50: 80nMAssay Description:Primary stock solutions of test compounds at a concentration of 6 mM were prepared from the 2 to 5 mg powder. The primary stock solutions of each tes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration against recombinant human (neuronal nitric oxide synthase) n-NOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50225106(NG-nitroarginine | 2-Amino-5-(N'-nitro-guanidino)-...)
Affinity DataIC50: 80nMAssay Description:Concentration required to inhibit neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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